Spinal Cord Injury AIS Predictions Using Machine Learning

• Published in: eNeuro 2023-01, Vol.10 (1), p.ENEURO.0149-22.2022
• Main Authors: Kapoor, Dhruv, Xu, Clark
• Format: Article
• Language: English
• Subjects: Humans; Machine Learning; New Research; Recovery of Function; Retrospective Studies; Spinal Cord Injuries - diagnosis
• ISSN: 2373-2822; 2373-2822
• DOI: 10.1523/ENEURO.0149-22.2022

The study used machine learning to predict The American Spinal Injury Association Impairment Scale (AIS) scores for newly injured spinal cord injury patients at hospital discharge time from hospital admission data. Additionally, machine learning was used to analyze the best model for feature importance to validate the criticality of the AIS score and highlight relevant demographic details. The data used for training machine learning models was from the National Spinal Cord Injury Statistical Center (NSCISC) database of U.S. spinal cord injury patient details. Eighteen real features were used from 417 provided features, which mapped to 53 machine learning features after processing. Eight models were tuned on the dataset to predict AIS scores, and Shapely analysis was performed to extract the most important of the 53 features. Patients within the NSCISC database who sustained injuries were between 1972 and 2016 after data cleaning (  = 20,790). Outcomes were test set multiclass accuracy and aggregated Shapely score magnitudes. Ridge Classifier was the best performer with 73.6% test set accuracy. AIS scores and neurologic category at the time of admission were the best predictors of recovery. Demographically, features were less important, but age, sex, marital status, and race stood out. AIS scores on admission are highly predictive of patient outcomes when combined with patient demographic data. Promising results in terms of predicting recovery were seen, and Shapely analysis allowed for the machine learning model to be probed as a whole, giving insight into overall feature trends.