Association between Infarct Location and Hemorrhagic Transformation of Acute Ischemic Stroke following Successful Recanalization after Mechanical Thrombectomy

• Published in: American journal of neuroradiology : AJNR 2023-01, Vol.44 (1), p.54-59
• Main Authors: Ni, H, Lu, G-D, Hang, Y, Jia, Z-Y, Cao, Y-Z, Shi, H-B, Liu, S, Zhao, L-B
• Format: Article
• Language: English
• Subjects: Adult Brain; Brain Ischemia - complications; Brain Ischemia - diagnostic imaging; Brain Ischemia - surgery; Cerebral Hemorrhage - complications; Cerebral Hemorrhage - etiology; Cerebral Infarction - diagnostic imaging; Cerebral Infarction - etiology; Cerebral Infarction - surgery; Humans; Interventional; Ischemic Stroke - diagnostic imaging; Ischemic Stroke - etiology; Ischemic Stroke - surgery; Retrospective Studies; Stroke - diagnostic imaging; Stroke - etiology; Stroke - surgery; Thrombectomy - adverse effects; Tomography, X-Ray Computed; Treatment Outcome
• ISSN: 0195-6108; 1936-959X
• DOI: 10.3174/ajnr.A7742

The association between infarct location and hemorrhagic transformation of acute ischemic stroke after mechanical thrombectomy is not understood. We aimed to evaluate the association between CTP-based ischemic core variables at admission and hemorrhagic transformation after a successful thrombectomy. We retrospectively analyzed patients who underwent endovascular thrombectomy for acute anterior circulation large-vessel occlusion between October 2019 and June 2021. We enrolled 146 patients with visible ischemic core on pretreatment CTP who had successful reperfusion. The ischemic core infarct territories were classified into the cortical and subcortical areas and then qualitatively and quantitatively analyzed by CTP. Logistic regression and receiver operating characteristic curve analyses were performed to determine the association between ischemic core variables and hemorrhagic transformation. Of the 146 patients analyzed, 72 (49.3%) had hemorrhagic transformation and 23 (15.8%) had symptomatic intracerebral hemorrhage. Multivariate analysis showed that subcortical infarcts were independently associated with hemorrhagic transformation (OR, 8.06; 95% CI, 2.31-28.10; = .001) and subcortical infarct volume was independently linked to symptomatic intracerebral hemorrhage (OR, 1.05; 95% CI, 1.01-1.09; = .039). The receiver operating characteristic curve indicated that subcortical infarcts can predict hemorrhagic transformation accurately (area under the curve = 0.755; 95% CI, 0.68-0.82;