Mind the gap—the use of sodium fluoresceine for resection of brain metastases to improve the resection rate

• Published in: Acta neurochirurgica 2023-01, Vol.165 (1), p.225-230
• Main Authors: Kerschbaumer, Johannes, Demetz, Matthias, Krigers, Aleksandrs, Pinggera, Daniel, Spinello, Antonio, Thomé, Claudius, Freyschlag, Christian F.
• Format: Article
• Language: English
• Subjects: Brain - pathology; Brain cancer; Brain Neoplasms - pathology; Brain tumors; Epidemiology; Female; Fluorescein; Fluorescence; Humans; Interventional Radiology; Magnetic resonance imaging; Male; Medicine; Medicine & Public Health; Metastases; Metastasis; Minimally Invasive Surgery; Neoplasm, Residual - surgery; Neurology; Neuroradiology; Neurosurgery; Original - Brain Tumors; Original Article - Brain Tumors; Patients; Radiation therapy; Retrospective Studies; Surgical Orthopedics; Survival; Tumors
• ISSN: 0942-0940; 0001-6268; 0942-0940
• DOI: 10.1007/s00701-022-05417-1

Introduction and purpose Brain metastases appear to be well resectable due to dissectable tumor margins, but postoperative MRI quite often depicts residual tumor with potential influence on tumor control and overall survival. Therefore, we introduced sodium fluoresceine into the routine workflow for brain metastasis resection. The aim of this study was to evaluate whether the use of fluorescence-guided surgery has an impact on postoperative tumor volume and local recurrence. Material and methods We retrospectively included patients who underwent surgical resection for intracranial metastases of systemic cancer between 11/2017 and 05/2021 at our institution. Tumor volumes were assessed pre- and postoperatively on T1-CE MRI. Clinical and epidemiological data as well as follow-up were gathered from our prospective database. Results Seventy-nine patients (33 male, 46 female) were included in this study. Median preoperative tumor volume amounted to 11.7cm 3 and fluoresceine was used in 53 patients (67%). Surgeons reported an estimated gross total resection (GTR) in 95% of the cases, while early postoperative MRI could confirm GTR in 72%. Patients resected using fluoresceine demonstrated significantly lower postoperative residual tumor volumes with a difference of 0.7cm 3 ( p  = 0.044) and lower risk of local tumor recurrence ( p  = 0.033). The use of fluorescence did not influence the overall survival (OS). Postoperative radiotherapy resulted in a significantly longer OS ( p  = 0.001). Discussion While GTR rates may be overrated, the use of intraoperative fluorescence may help neurosurgeons to achieve a more radical resection. Fluoresceine seems to facilitate surgical resection and increase the extent of resection thus reducing the risk for local recurrence.