Pregnancy Outcomes in Women with PCOS: Follow-Up Study of a Randomized Controlled Three-Component Lifestyle Intervention

Women with polycystic ovary syndrome (PCOS) and excess weight often present with reproductive derangements. The first-line treatment for this population is a multi-component lifestyle intervention. This follow-up study of a randomized controlled trial based on data from the Dutch Perinatal registry...

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Bibliographic Details
Published in:Journal of clinical medicine 2023-01, Vol.12 (2), p.426
Main Authors: Dietz de Loos, Alexandra, Jiskoot, Geranne, Louwers, Yvonne, Beerthuizen, Annemerle, Busschbach, Jan, Laven, Joop
Format: Article
Language:English
Subjects:
Birth weight
Body mass index
Clinical medicine
Cognitive behavioral therapy
Diabetes
Exercise
Gestational age
Hypertension
Infertility
Intervention
Lifestyles
Obesity
Ovaries
Overweight
Physical fitness
Polycystic ovary syndrome
Pregnancy complications
Premature birth
Survival analysis
Weight control
Womens health
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Summary:Women with polycystic ovary syndrome (PCOS) and excess weight often present with reproductive derangements. The first-line treatment for this population is a multi-component lifestyle intervention. This follow-up study of a randomized controlled trial based on data from the Dutch Perinatal registry was conducted to study the effect of a one-year three-component (cognitive behavioral therapy, healthy diet, and exercise) lifestyle intervention on pregnancy outcomes in women with PCOS and overweight or obesity. Women diagnosed with PCOS, a BMI ≥ 25 kg/m², and a wish to conceive were randomized to either three-component lifestyle intervention (LSI, n = 123), and care as usual (CAU, n = 60) where they were encouraged to lose weight autonomously. Conception resulting in live birth was 39.8% (49/123) within LSI and 38.3% (23/60) within CAU ( = 0.845). In total, 58.3% conceived spontaneously. Gestational diabetes (LSI: 8.2% vs. CAU: 21.7%, = 0.133), hypertensive disorders (LSI: 8.2% vs. CAU 13.0%, = 0.673), and preterm birth (LSI: 12.2% vs. CAU: 17.4%, = 0.716) rates were all lower in LSI compared to CAU. This follow-up study showed no significant differences in conception resulting in live birth rates between LSI and CAU. Nonetheless, a large proportion eventually conceived spontaneously. Moreover, after LSI, the number of uneventful pregnancies was lower compared to care as usual.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm12020426