Societal Preferences for Meningococcal B Vaccination in Children: A Discrete Choice Experiment in Spain

Introduction Immunization is the most effective strategy for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B (MenB); however, parents need to weigh the risk–benefit and financial impact of immunizing their children against MenB in the absence of a nation...

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Published in:Infectious diseases and therapy 2023-01, Vol.12 (1), p.157-175
Main Authors: Martinón-Torres, Federico, de Miguel, Ángel Gil, Ruiz-Contreras, Jesús, Vallejo-Aparicio, Laura A., García, Andrea, Gonzalez-Inchausti, María C., de Gomensoro, Eduardo, Kocaata, Zeki, Gabás-Rivera, Clara, Comellas, Marta, Prades, Miriam, Lizán, Luis
Format: Article
Language:English
Subjects:
Analysis
Decision-making
Immunization
Infectious Diseases
Internal Medicine
Literature reviews
Medicine
Medicine & Public Health
Meningitis
Original Research
Parents & parenting
Pediatrics
Prevention
Social aspects
Surveys
Vaccination
Vaccines
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Summary:Introduction Immunization is the most effective strategy for the prevention of invasive meningococcal disease caused by Neisseria meningitidis serogroup B (MenB); however, parents need to weigh the risk–benefit and financial impact of immunizing their children against MenB in the absence of a national immunization program (NIP). This study aimed to explore societal preferences (of parents and pediatricians) regarding the attributes of a MenB vaccine in Spain. Methods A discrete choice experiment (DCE) based on cross-sectional surveys was carried out to determine preferences. A literature review and scientific committee determined the six attributes related to the MenB vaccine included in the DCE: vaccination age, cost, duration, percentage of protection, adverse events probability, and expert/authority recommendation. Data were analyzed using a mixed logit model. Relative importance (RI) of attributes was calculated and compared between parents and pediatricians. Results A total of 278 parents [55.8% female, mean age 40.4 (standard deviation, SD 7.3) years] and 200 pediatricians [73.0% female, mean age 45.8 (SD 12.9) years] answered the DCE. For parents, the highest RI was attributed to vaccine cost, expert/authority recommendation, and percentage of protection (26.4%, 26.1%, and 22.9%, respectively), while for pediatricians the highest RI was assigned to percentage of protection, expert/authority recommendation, and vaccination age (27.2%, 23.7%, and 22.6%, respectively). Significant differences between parents and pediatricians were found in the RI assigned to all attributes ( p 
ISSN:2193-8229
2193-6382
DOI:10.1007/s40121-022-00708-7