High-dose intravenous anakinra treatment is safe and effective in severe and critical COVID-19 patients: a propensity score-matched study in a single center

• Published in: Inflammopharmacology 2023-04, Vol.31 (2), p.787-797
• Main Authors: Bektaş, Murat, Yüce, Servet, Ay, Mustafa, Uyar, Muhammed Hamdi, Önder, Mustafa Erkut, Kılıç, Muhammed İkbal
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Allergology; Biomedical and Life Sciences; Biomedicine; COVID-19; Dermatology; Gastroenterology; Humans; Immunology; Interleukin 1 Receptor Antagonist Protein - adverse effects; Male; Middle Aged; Original; Original Article; Pharmacology/Toxicology; Propensity Score; Retrospective Studies; Rheumatology; SARS-CoV-2
• ISSN: 0925-4692; 1568-5608
• DOI: 10.1007/s10787-023-01138-8

Background In COVID-19, severe disease course such as need of intensive care unit (ICU) as well as development of mortality is mainly due to cytokine storm. In this study, we aimed to evaluate the high-dose intravenous anakinra treatment response and outcome in patients with severe and critically ill COVID-19 compared to standard of care. Methods This retrospective observational study was carried out at a tertiary referral center. The study population consisted of two groups as follows: the patients receiving high-dose intravenous anakinra (anakinra group) between 01.09.2021 and 01.02.2022 and the patients treated with standard of care (SoC, control group) as historical control group who were hospitalized between 01.07.2021 and 01.09.2021. Results After the propensity score 1:1 matching, 79 patients in anakinra and 79 patients in SoC matched and were included into the analysis. Mean ± SD patient age was 67.4 ± 16.7 and 67.1 ± 16.3 years in anakinra and SoC groups, respectively ( p  = 0.9). Male gender was 38 (48.7%) in anakinra and 36 (46.2%) in SoC ( p  = 0.8). Overall, ICU admission was in 14.1% ( n  = 11) and 30.8% ( n  = 24) ( p  = 0.013; OR 6.2), intubation in 12.8% ( n  = 10) and 16.7% ( n  = 13) patients ( p  = 0.5), and 14.1% ( n  = 11) and 32.1% ( n  = 25) patients died in anakinra and control groups, respectively ( p  = 0.008; OR 7.1). Conclusion In our study, mortality was lower in patients receiving anakinra compared to SoC. Intravenous high-dose anakinra is safe and effective treatment in patients with severe and critical COVID-19.