Transmural remission improves clinical outcomes up to 5 years in Crohn's disease

Introduction Evidence supporting transmural remission (TR) as a long‐term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long‐term. Met...

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Published in:United European gastroenterology journal 2023-02, Vol.11 (1), p.51-59
Main Authors: Fernandes, Samuel Raimundo, Serrazina, Juliana, Botto, Inês Ayala, Leal, Tiago, Guimarães, Andreia, Garcia, Joana Lemos, Rosa, Isadora, Prata, Rita, Carvalho, Diana, Neves, João, Campelo, Pedro, Ventura, Sofia, Silva, Andrea, Coelho, Mariana, Sequeira, Cristiana, Oliveira, Ana Paula, Portela, Francisco, Ministro, Paula, Tavares de Sousa, Helena, Ramos, Jaime, Claro, Isabel, Gonçalves, Raquel, Correia, Luís Araújo, Marinho, Rui Tato, Cortez‐Pinto, Helena, Magro, Fernando
Format: Article
Language:English
Subjects:
Clinical outcomes
Colonoscopy
Crohn Disease - diagnostic imaging
Crohn Disease - drug therapy
Crohn's disease
Demographics
Drug dosages
Endoscopy
Hospitalization
Humans
Immunomodulators
Inflammation
Inflammatory Bowel Disease
Magnetic Resonance Imaging - methods
MRI enterography
Original
Remission (Medicine)
Remission Induction
Retrospective Studies
Small intestine
Statistical analysis
Steroids
Surgery
transmural remission
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Summary:Introduction Evidence supporting transmural remission (TR) as a long‐term treatment target in Crohn's disease (CD) is still unavailable. Less stringent but more reachable targets such as isolated endoscopic (IER) or radiologic remission (IRR) may also be acceptable options in the long‐term. Methods Multicenter retrospective study including 404 CD patients evaluated by magnetic resonance enterography and colonoscopy. Five‐year rates of hospitalization, surgery, use of steroids, and treatment escalation were compared between patients with TR, IER, IRR, and no remission (NR). Results 20.8% of CD patients presented TR, 23.3% IER, 13.6% IRR and 42.3% NR. TR was associated with lower risk of hospitalization (odds‐ratio [OR] 0.244 [0.111–0.538], p 
ISSN:2050-6406
2050-6414
DOI:10.1002/ueg2.12356