Behavioral origin of sound-evoked activity in mouse visual cortex

Sensory cortices can be affected by stimuli of multiple modalities and are thus increasingly thought to be multisensory. For instance, primary visual cortex (V1) is influenced not only by images but also by sounds. Here we show that the activity evoked by sounds in V1, measured with Neuropixels prob...

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Bibliographic Details
Published in:Nature neuroscience 2023-02, Vol.26 (2), p.251-258
Main Authors: Bimbard, Célian, Sit, Timothy P. H., Lebedeva, Anna, Reddy, Charu B., Harris, Kenneth D., Carandini, Matteo
Format: Article
Language:English
Subjects:
631/378/2613/1875
631/378/2619/2618
631/378/3917
Acoustic Stimulation
Animal Genetics and Genomics
Animals
Auditory Cortex - physiology
Auditory Perception - physiology
Behavioral Sciences
Biological Techniques
Biomedical and Life Sciences
Biomedicine
Cortex (auditory)
Cortex (somatosensory)
Hearing
Hippocampus
Mice
Neurobiology
Neurons - physiology
Neurosciences
Sound
Visual cortex
Visual Cortex - physiology
Visual Perception - physiology
Visual stimuli
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Summary:Sensory cortices can be affected by stimuli of multiple modalities and are thus increasingly thought to be multisensory. For instance, primary visual cortex (V1) is influenced not only by images but also by sounds. Here we show that the activity evoked by sounds in V1, measured with Neuropixels probes, is stereotyped across neurons and even across mice. It is independent of projections from auditory cortex and resembles activity evoked in the hippocampal formation, which receives little direct auditory input. Its low-dimensional nature starkly contrasts the high-dimensional code that V1 uses to represent images. Furthermore, this sound-evoked activity can be precisely predicted by small body movements that are elicited by each sound and are stereotyped across trials and mice. Thus, neural activity that is apparently multisensory may simply arise from low-dimensional signals associated with internal state and behavior. Sounds evoke activity in visual cortex. Bimbard et al. find that this activity is stereotyped across cells, not specific to visual cortex, independent of inputs from auditory cortex and predicted by stereotyped movements elicited by the sounds.
ISSN:1097-6256
1546-1726
DOI:10.1038/s41593-022-01227-x