Organs-on-a-chip: a union of tissue engineering and microfabrication

HighlightsConceived to address challenges in modeling human biology, organ-on-a-chip (OOAC) engineering has grown enormously from tissue engineering to capture specific hallmarks of human tissues. The evolution of OOAC models is intertwined with progress in tissue engineering by applying cellular co...

Full description

Saved in:
Bibliographic Details
Published in:Trends in biotechnology (Regular ed.) 2023-03, Vol.41 (3), p.410-424
Main Authors: Zhao, Yimu, Wang, Erika Yan, Lai, Fook B.L, Cheung, Krisco, Radisic, Milica
Format: Article
Language:English
Subjects:
3-D printers
Biochips
Biomedical materials
Cardiomyocytes
disease modeling
Drug development
drug testing
Engineers
Fibroblasts
Heart
high throughput
Human tissues
Humans
Hyaluronic acid
Hydrogels
Internal Medicine
Lab-On-A-Chip Devices
Liver
microfabrication
Microfluidics
Microfluidics - methods
Microtechnology
miniaturization
organ-on-a-chip
Regulatory approval
Reproducibility
Stem cells
Tissue engineering
Tissue Engineering - methods
Toxicity
Vascularization
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:HighlightsConceived to address challenges in modeling human biology, organ-on-a-chip (OOAC) engineering has grown enormously from tissue engineering to capture specific hallmarks of human tissues. The evolution of OOAC models is intertwined with progress in tissue engineering by applying cellular components, biomaterials, and tissue culture technologies. The manufacture of OOAC devices incorporates microfabrication techniques, material chemistry, and biosensing applications. Current OOAC platforms focus on constructing higher-order structures using tissue engineering principles. For example, liver- and heart-on-chips are used to study drug metabolism, toxicity, and pathology. Limitations in the OOAC field include achieving systematic biomimicry and stability. Synergistic incorporation of advanced cell culture and manufacturing techniques can expand the impact of OOAC platforms.
ISSN:0167-7799
1879-3096
1879-3096
DOI:10.1016/j.tibtech.2022.12.018