Olfactory cleft mass as the first presentation of asymptomatic metastatic renal cell carcinoma: A case report and review of the literature

• Published in: International journal of surgery case reports 2023-03, Vol.104, p.107943, Article 107943
• Main Authors: Hasnaoui, Mehdi, Chebil, Azer, Masmoudi, Mohamed, Bellalah, Ahlem, Zakhama, Abdelfattah, Mighri, Khalifa
• Format: Article
• Language: English
• Subjects: Case Report; Metastasis; Nose neoplasms; Olfactory cleft; Paranasal sinus neoplasms; Renal carcinoma; Renal cell cancer
• ISSN: 2210-2612; 2210-2612
• DOI: 10.1016/j.ijscr.2023.107943

Renal cell carcinoma metastasis in the sinonasal cavities is rare. They account for less than 1 % of all metastases of these renal cancers. We report the case of a patient with an unremarkable pathological history, who consulted for recurrent right epistaxis. Nasal endoscopy revealed a reddish mass located medial to the right middle turbinate. Computed tomography and magnetic resonance imaging showed a lesion located at the level of the olfactory cleft. The patient had a complete removal of the mass and the anatomopathological examination concluded to a metastasis of a clear cell carcinoma of renal origin. Taking into account these results, a thoraco-abdomino-pelvic CT scan was performed and it discovered a left renal tumor. The most frequent functional sign of Renal cell carcinoma metastases is epistaxis. This is explained by the rich vascularity of these metastases. The imaging data are not specific and do not allow differentiation between primary tumor and metastasis. The definitive diagnosis can be confirmed only by histologic examination. Faced with any hypervascularized tumor of the nasal cavity, the ENT physician must evoke a metastasis of a renal cancer, even in the absence of history and symptoms evoking this cancer. •Faced with any hypervascularized tumor of the nasal cavity, the ENT physician must evoke a metastasis of a renal cancer.•The imaging data are not specific. The definitive diagnosis can be confirmed only by histologic examination.•Surgery is indicated for single, resectable metastases.•Immunotherapy is currently a good therapeutic alternative in the event of multiple or inoperable metastases.