Hyperoxia impairs intraflagellar transport and causes dysregulated metabolism with resultant decreased cilia length

Supplemental oxygen is a lifesaving measure in infants born premature to facilitate oxygenation. Unfortunately, it may lead to alveolar simplification and loss of proximal airway epithelial cilia. Little is known about the mechanism by which hyperoxia causes ciliary dysfunction in the proximal respi...

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Bibliographic Details
Published in:American journal of physiology. Lung cellular and molecular physiology 2023-03, Vol.324 (3), p.L325-L334
Main Authors: Teape, Daniella, Peterson, Abigail, Ahsan, Nagib, Ellis, Kimberlyn, Correia, Nicholas, Luo, Ryan, Hegarty, Katy, Yao, Hongwei, Dennery, Phyllis
Format: Article
Language:English
Subjects:
Animals
Biological Transport
Cilia - metabolism
Dyneins
Humans
Hyperoxia - metabolism
Lung - metabolism
Mice
Proteins - metabolism
Proteomics
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Summary:Supplemental oxygen is a lifesaving measure in infants born premature to facilitate oxygenation. Unfortunately, it may lead to alveolar simplification and loss of proximal airway epithelial cilia. Little is known about the mechanism by which hyperoxia causes ciliary dysfunction in the proximal respiratory tract. We hypothesized that hyperoxia causes intraflagellar transport (IFT) dysfunction with resultant decreased cilia length. Differentiated basal human airway epithelial cells (HAEC) were exposed to hyperoxia or air for up to 48 h. Neonatal mice (
ISSN:1040-0605
1522-1504
DOI:10.1152/ajplung.00522.2021