Surgeon experience in glioblastoma surgery of the elderly—a multicenter, retrospective cohort study

Purpose To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis. Methods GBM patients aged ≥ 65 years who underwent tumor re...

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Bibliographic Details
Published in:Journal of neuro-oncology 2023-02, Vol.161 (3), p.563-572
Main Authors: Pöppe, Johannes P., Machegger, Lukas, Steinbacher, Jürgen, Stefanits, Harald, Eisschiel, Sophie, Gruber, Andreas, Demetz, Matthias, Ladisich, Barbara, Kraus, Theo F.J., Weis, Serge, Spiegl-Kreinecker, Sabine, Romagna, Alexander, Griessenauer, Christoph J., Jahromi, Behnam Rezai, Rautalin, Ilari, Niemelä, Mika, Korja, Miikka, Schwartz, Christoph
Format: Article
Language:English
Subjects:
Aged
Brain cancer
Brain Neoplasms - pathology
Brain tumors
Cohort analysis
Glioblastoma
Glioblastoma - pathology
Hospitals, Teaching
Humans
Medicine
Medicine & Public Health
Morbidity
Neurology
Neurosurgeons
Neurosurgical Procedures - methods
Oncology
Patients
Retrospective Studies
Surgery
Survival
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Summary:Purpose To assess the impact of individual surgeon experience on overall survival (OS), extent of resection (EOR) and surgery-related morbidity in elderly patients with glioblastoma (GBM), we performed a retrospective case-by-case analysis. Methods GBM patients aged ≥ 65 years who underwent tumor resection at two academic centers were analyzed. The experience of each neurosurgeon was quantified in three ways: (1) total number of previously performed glioma surgeries (lifetime experience); (2) number of surgeries performed in the previous five years (medium-term experience) and (3) in the last two years (short-term experience). Surgeon experience data was correlated with survival (OS) and surrogate parameters for surgical quality (EOR, morbidity). Results 198 GBM patients (median age 73.0 years, median preoperative KPS 80, IDH-wildtype status 96.5%) were included. Median OS was 10.0 months (95% CI 8.0–12.0); median EOR was 89.4%. Surgery-related morbidity affected 19.7% patients. No correlations of lifetime surgeon experience with OS (P = .693), EOR (P = .693), and surgery-related morbidity (P = .435) were identified. Adjuvant therapy was associated with improved OS (P 
ISSN:0167-594X
1573-7373
DOI:10.1007/s11060-023-04252-3