The Activation of Cellular Genes in Transformed Cells

We have used differential cDNA cloning techniques to isolate a number of genes that are activated as a result of transformation by the DNA tumour virus Simian virus 40. From the nucleotide sequences of the cDNA clones we have been able to identify some of these genes. One of them derives from the ma...

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Bibliographic Details
Published in:Philosophical transactions of the Royal Society of London. Series B, Biological sciences Biological sciences, 1984-12, Vol.307 (1132), p.347-351
Main Authors: Rigby, P. W. J., Brickell, P. M., Latchman, D. S., Murphy, D., K.-H. Westphal, Willison, K.
Format: Article
Language:English
Subjects:
Animals
Cell lines
Cell Transformation, Viral
Cells, Cultured
Cloning, Molecular
Complementary DNA
DNA - metabolism
Embryonic stem cells
Genes
Major Histocompatibility Complex
Messenger RNA
Mice
Mice, Inbred BALB C
Pluripotent stem cells
Repetitive Sequences, Nucleic Acid
RNA
RNA, Messenger - genetics
Simian virus 40 - genetics
Stem cells
Transcription, Genetic
Transformed cell line
Viral tumor antigens
Citations: Items that this one cites
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Summary:We have used differential cDNA cloning techniques to isolate a number of genes that are activated as a result of transformation by the DNA tumour virus Simian virus 40. From the nucleotide sequences of the cDNA clones we have been able to identify some of these genes. One of them derives from the major histocompatibility complex and contains a repetitive element that identifies a large number of RNAs present in pluripotential embryonic cells.
ISSN:0962-8436
0080-4622
1471-2970
2054-0280
DOI:10.1098/rstb.1984.0138