Asymmetric synthesis of bis-tetrahydrofuran cores in annonaceous acetogeninsDedicated to Prof. John C. Gilbert on the occasion of his 70th birthday.Electronic supplementary information (ESI) available: Experimental procedures and NMR spectra for all key compounds. See DOI: 10.1039/c004672h

The bis-THF cores of annonaceous acetogenins were synthesized using (3 R ,4 R )-1,5-hexadiene-3,4-diol ( 1 ) as the sole source of carbon atoms. The methylene acetal function was applied as a new linker/tether to facilitate the ring-closing metathesis. The bis-THF cores were synthesized from (3 R ,4...

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Main Authors: Chen, Chia-Hsiu, Kuan, Ting-Chun, Lu, Ke-Jhen, Hou, Duen-Ren
Format: Article
Language:English
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Summary:The bis-THF cores of annonaceous acetogenins were synthesized using (3 R ,4 R )-1,5-hexadiene-3,4-diol ( 1 ) as the sole source of carbon atoms. The methylene acetal function was applied as a new linker/tether to facilitate the ring-closing metathesis. The bis-THF cores were synthesized from (3 R ,4 R )-1,5-hexadiene-3,4-diol, and the methylene acetal function was developed as a new linker for RCM.
ISSN:1477-0520
1477-0539
DOI:10.1039/c004672h