Synthesis and biological evaluation of substituted α- and β-2,3-dihydrofuran naphthoquinones as potent anticandidal agentsElectronic supplementary information (ESI) available: Materials, methods, preparation and spectroscopic data of the naphthoquinones derivatives; Potential hemolytic of compounds tested; Toxicity test in NIH3T3 Cell Culture; Antifungal tests. See DOI: 10.1039/c0md00074d

• Main Authors: Freire, Cristina Pessoa Veloso, Ferreira, Sabrina Baptista, de Oliveira, Nivea Suely Melo, Matsuura, Ani Beatriz Jackisch, Gama, Ivson Lelis, da Silva, Fernando de C, de Souza, Maria Cecília B. V, Lima, Emerson Silva, Ferreira, Vitor Francisco
• Format: Article
• Language: English
• ISSN: 2040-2503; 2040-2511
• DOI: 10.1039/c0md00074d

We report herein, the synthesis and antifungal activity of substituted α- and β-dihydrofuran naphthoquinones. These compounds were prepared from readily available lawsone and olefins in the presence of cerium( iv ) ammonium nitrate (CAN) and were then evaluated against the following six strains of Candida ( C. ): C. albicans , C. krusei , C. parapsilosis , C. kefyr , C. tropicalis and C. dubliniensis . In addition to exhibiting low cytotoxicity, the furan naphthoquinones proved to be active against these fungi, indicating that they are important scaffolds and potential novel antifungal agents. We report the synthesis of substituted α- and β-dihydrofuran naphthoquinones.