A copper-mediated cyclization reaction of hydrazine with enediynones providing pyrazolo[1,5-a]pyridinesElectronic supplementary information (ESI) available: Representative experimental procedure and spectroscopic data for all newly synthesized products. CCDC reference numbers 792989-792991. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c0ob00756k

2,7-Disubstituted pyrazolo[1,5- a ]pyridines were synthesized in good chemical yields by the reaction of enediynones with hydrazine, followed by addition of copper chloride. This reaction can tolerate many functional groups. This article describes a unique tandem cyclization of enediyne to give 2,7-...

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Main Authors: Wu, Hung-Chou, Hwang, Long-Chih, Wu, Ming-Jung
Format: Article
Language:English
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Summary:2,7-Disubstituted pyrazolo[1,5- a ]pyridines were synthesized in good chemical yields by the reaction of enediynones with hydrazine, followed by addition of copper chloride. This reaction can tolerate many functional groups. This article describes a unique tandem cyclization of enediyne to give 2,7-disubstituted pyrazolo[1,5- a ]pyridines by the reaction of hydrazine with enediynones mediated by copper chloride.
ISSN:1477-0520
1477-0539
DOI:10.1039/c0ob00756k