Expanded substrate scope and catalyst optimization for the catalytic kinetic resolution of N-heterocyclesElectronic supplementary information (ESI) available: Experimental data, NMR titration, and NMR spectra. See DOI: 10.1039/c2cc34907h

The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possib...

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Main Authors: Hsieh, Sheng-Ying, Binanzer, Michael, Kreituss, Imants, Bode, Jeffrey W
Format: Article
Language:English
Online Access:Get full text
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Summary:The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol. In addition to increasing selectivity across all substrates, these conditions make possible the resolution of N-heterocycles containing lactams or other basic functional groups that can inhibit the catalyst. The scope, reactivity, and selectivity of the chiral hydroxamic acid-catalyzed kinetic resolution of chiral amines are improved by a new catalyst structure and a more environmentally friendly reaction protocol.
ISSN:1359-7345
1364-548X
DOI:10.1039/c2cc34907h