A regio- and diastereoselective palladium-catalyzed cyclopropanation of norbornene derivatives with molecular oxygen as the sole oxidantElectronic supplementary information (ESI) available: Experimental section, characterization of all compounds, copies of 1H and 13C NMR spectra for selected compounds. CCDC 890795. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c2cc35124b

• Main Authors: Wu, Wanqing, Jiang, Huanfeng, Gao, Yang, Huang, Huawen, Zeng, Wei, Cao, Derong
• Format: Article
• Language: English
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c2cc35124b

A mild and efficient Pd-catalyzed cyclopropanation of norbornene derivatives with tertiary propargylic alcohols using molecular oxygen as the sole oxidant is described. This process allows quick and atom-economical assembly of various 1,2,3-trisubstituted cyclopropanes bearing α,β-unsaturated ketone moieties in high yields as a single regio- and diastereoisomer. A Pd-catalyzed cyclopropanation of norbornenes using O 2 as the oxidant is described, which affords 1,2,3-trisubstituted cyclopropanes with high yields and selectivities.