Efficient synthesis of isoquinolines and pyridines via copper(i)-catalyzed multi-component reactionElectronic supplementary information (ESI) available: Copies of 1H NMR, 13C NMR spectra of 2a-y and MTT assay protocol. See DOI: 10.1039/c3ra46722h

A wide range of 3-substituted isoquinolines, steroidal pyridines, 5,6-dihydrobenzo[ f ]isoquinolines and 1,6-naphthyridine were synthesized in good yield via a ligand-free copper-catalyzed three-component reaction of β-halovinyl/aryl aldehyde, aromatic/aliphatic terminal alkyne and tert -butylamine/...

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Main Authors: Shekarrao, Kommuri, Kaishap, Partha Pratim, Gogoi, Sanjib, Boruah, Romesh C
Format: Article
Language:English
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Summary:A wide range of 3-substituted isoquinolines, steroidal pyridines, 5,6-dihydrobenzo[ f ]isoquinolines and 1,6-naphthyridine were synthesized in good yield via a ligand-free copper-catalyzed three-component reaction of β-halovinyl/aryl aldehyde, aromatic/aliphatic terminal alkyne and tert -butylamine/benzamidine in DMF under microwave irradiation. A catalyst-free reaction of ortho -alkynyl aryl/vinyl aldehydes with benzamidine under microwave irradiation also provided the 3-substituted isoquinoline and substituted pyridine derivatives in excellent yield. A wide range of 3-substituted isoquinolines, steroidal pyridines, 5,6-dihydrobenzo[ f ]isoquinolines and 1,6-naphthyridine were synthesized in good yield via a ligand-free copper-catalyzed 3-component reaction of β-halovinyl/aryl aldehyde, aromatic/aliphatic terminal alkyne and tert -butylamine/benzamidine in DMF under microwave irradiation.
ISSN:2046-2069
DOI:10.1039/c3ra46722h