Synthesis of spongistatin 2 employing a new route to the EF fragmentElectronic supplementary information (ESI) available. See DOI: 10.1039/c3sc50304f

An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2. The C48-C51 diene side chain, which lacks the chlorine substituent present in spongistatin 1, presented some compatibility issues during target assembly. These were overcome by...

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Main Authors: Kraus, Helmut, Français, Antoine, O'Brien, Matthew, Frost, James, Diéguez-Vázquez, Alejandro, Polara, Alessandra, Baricordi, Nikla, Horan, Richard, Hsu, Day-Shin, Tsunoda, Takashi, Ley, Steven V
Format: Article
Language:English
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Summary:An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2. The C48-C51 diene side chain, which lacks the chlorine substituent present in spongistatin 1, presented some compatibility issues during target assembly. These were overcome by implementing a late stage Stille cross coupling to construct the diene portion of the natural product. An improved route to the EF fragment of the spongistatins has been developed and employed in a synthesis of spongistatin 2.
ISSN:2041-6520
2041-6539
DOI:10.1039/c3sc50304f