Enantio- and diastereoselective synthesis of γ-amino alcoholsElectronic supplementary information (ESI) available: Experimental data, characterization data and crystal data and structure refinements. CCDC 1400959. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c5cc04445f

• Main Authors: Verkade, Jorge M. M, Quaedflieg, Peter J. L. M, Verzijl, Gerard K. M, Lefort, Laurent, van Delft, Floris L, de Vries, Johannes G, Rutjes, Floris P. J. T
• Format: Article
• Language: English
• ISSN: 1359-7345; 1364-548X
• DOI: 10.1039/c5cc04445f

The γ-amino alcohol structural motif is often encountered in drugs and natural products. We developed two complementary catalytic diastereoselective methods for the synthesis of N -PMP-protected γ-amino alcohols from the corresponding ketones. The anti -products were obtained through Ir-catalyzed asymmetric transfer hydrogenation, the syn -products via Rh-catalyzed asymmetric hydrogenation. Two complementary catalytic diastereoselective methods for the synthesis of N -PMP-protected γ-amino alcohols from the corresponding ketones have been developed.