Catalytic carbonyl hydrosilylations via a titanocene borohydride-PMHS reagent systemElectronic supplementary information (ESI) available: Experimental details, IR and NMR spectra. See DOI: 10.1039/c7cy01088e

Reduction of a wide range of aldehydes and ketones with catalytic amounts of titanocene borohydride in concert with a stoichiometric poly(methylhydrosiloxane) (PMHS) reductant is reported. Preliminary mechanistic studies demonstrate that the reaction is mediated by a reactive titanocene( iii ) compl...

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Main Authors: Fianu, Godfred D, Schipper, Kyle C, Flowers II, Robert A
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description Reduction of a wide range of aldehydes and ketones with catalytic amounts of titanocene borohydride in concert with a stoichiometric poly(methylhydrosiloxane) (PMHS) reductant is reported. Preliminary mechanistic studies demonstrate that the reaction is mediated by a reactive titanocene( iii ) complex, whose oxidation state remains constant throughout the reaction. Catalytic amounts of titanocene( iii ) borohydride, generated under mild conditions from commercially available titanocene dichloride, in concert with a stoichiometric hydride source is shown to effectively reduce aldehydes and ketones to their respective alcohols in aprotic media.
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title Catalytic carbonyl hydrosilylations via a titanocene borohydride-PMHS reagent systemElectronic supplementary information (ESI) available: Experimental details, IR and NMR spectra. See DOI: 10.1039/c7cy01088e
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