Visible-light-promoted intramolecular C-H amination in aqueous solution: synthesis of carbazolesElectronic supplementary information (ESI) available. See DOI: 10.1039/c7gc03392c

An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as a co-solvent, visible-light rather than various metals is used to facilitate the conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactiv...

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Bibliographic Details
Main Authors: Yang, Lizheng, Zhang, Yipin, Zou, Xiaodong, Lu, Hongjian, Li, Guigen
Format: Article
Language:English
Online Access:Get full text
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Summary:An effective and operationally simple protocol is reported for the synthesis of versatile carbazoles. With water as a co-solvent, visible-light rather than various metals is used to facilitate the conversion of readily available 2-azidobiphenyls under mild conditions. Various functionalized bioactive natural alkaloids, such as glycoborine, clausine C, clausine L, clausine H and clauszoline K, were synthesized efficiently with nitrogen as a sole byproduct. The reaction could be performed in water, acidic or alkaline buffer solutions, showing its potential for applications in biochemistry. Visible light rather than various metals is reported to promote the synthesis of various carbazoles from readily available 2-azidobiphenyls under mild conditions.
ISSN:1463-9262
1463-9270
DOI:10.1039/c7gc03392c