Regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2-a]pyridines by Suzuki-Miyaura and Sonogashira cross-coupling reactionsElectronic supplementary information (ESI) available. CCDC 1537566. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7ob00624a

An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2- a ]pyridine was developed. This sequence allowed the selective introduction of aryl, heteroaryl, alkyl and alkynyl substituents at both 2- and 3-positions, by using Suzuki-Miyaura and Sonogashira cross-coupling r...

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Main Authors: Delaye, P.-O, Pénichon, M, Allouchi, H, Enguehard-Gueiffier, C, Gueiffier, A
Format: Article
Language:English
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Summary:An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2- a ]pyridine was developed. This sequence allowed the selective introduction of aryl, heteroaryl, alkyl and alkynyl substituents at both 2- and 3-positions, by using Suzuki-Miyaura and Sonogashira cross-coupling reactions. A library of compounds diversely substituted on 2- and 3-positions can be easily prepared from a common, stable and easily accessible starting material. An efficient method for regiocontrolled functionalization of 2,3-dihalogenoimidazo[1,2- a ]pyridine was developed.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob00624a