Synthesis of 3-acylindoles by oxidative rearrangement of 2-aminochalcones using a hypervalent iodine reagent and cyclization sequenceElectronic supplementary information (ESI) available. See DOI: 10.1039/c7ob01536d

An efficient one-pot method was developed for the construction of 3-acylindoles via oxidative rearrangement of 2-aminochalcones followed by intramolecular cyclization. The reaction was used to convert a variety of 2-aminochalcones into 3-acylindoles in moderate to high yields. An efficient one-pot 3...

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Main Authors: Nakamura, Akira, Tanaka, Satoshi, Imamiya, Akira, Takane, Reo, Ohta, Chiaki, Fujimura, Kazuma, Maegawa, Tomohiro, Miki, Yasuyoshi
Format: Article
Language:English
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Summary:An efficient one-pot method was developed for the construction of 3-acylindoles via oxidative rearrangement of 2-aminochalcones followed by intramolecular cyclization. The reaction was used to convert a variety of 2-aminochalcones into 3-acylindoles in moderate to high yields. An efficient one-pot 3-acylindole synthesis by oxidative rearrangement of 2-aminochalcones and sequential cyclization has been developed.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob01536d