Base promoted direct difunctionalization/cascade cyclization of 1,6-enynes

A novel base-mediated direct difluoroalkylation of 1,6-enynes involving a CF 2 radical process has been developed. In the absence of metal catalysts, two different difluoroalkylated cyclization products have been synthesized with good functional group applicability and high stereoselectivity. Notabl...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2018-05, Vol.54 (42), p.5334-5337
Main Authors: Li, Ming, Wang, Cui-Tian, Qiu, Yi-Feng, Zhu, Xin-Yu, Han, Ya-Ping, Xia, Yu, Li, Xue-Song, Liang, Yong-Min
Format: Article
Language:English
Subjects:
Chemical synthesis
Functional groups
Stereoselectivity
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Summary:A novel base-mediated direct difluoroalkylation of 1,6-enynes involving a CF 2 radical process has been developed. In the absence of metal catalysts, two different difluoroalkylated cyclization products have been synthesized with good functional group applicability and high stereoselectivity. Notably, the properties of a base have been shown to play a crucial role in the generation selectivity of this transformation. A novel base-mediated direct difluoroalkylation of 1,6-enynes involving a CF 2 radical process has been developed.
ISSN:1359-7345
1364-548X
DOI:10.1039/c8cc03280g