Base promoted direct difunctionalization/cascade cyclization of 1,6-enynes

A novel base-mediated direct difluoroalkylation of 1,6-enynes involving a CF 2 radical process has been developed. In the absence of metal catalysts, two different difluoroalkylated cyclization products have been synthesized with good functional group applicability and high stereoselectivity. Notabl...

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Published in:Chemical communications (Cambridge, England) England), 2018-05, Vol.54 (42), p.5334-5337
Main Authors: Li, Ming, Wang, Cui-Tian, Qiu, Yi-Feng, Zhu, Xin-Yu, Han, Ya-Ping, Xia, Yu, Li, Xue-Song, Liang, Yong-Min
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Language:English
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Chemical synthesis
Functional groups
Stereoselectivity
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container_title Chemical communications (Cambridge, England)
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description A novel base-mediated direct difluoroalkylation of 1,6-enynes involving a CF 2 radical process has been developed. In the absence of metal catalysts, two different difluoroalkylated cyclization products have been synthesized with good functional group applicability and high stereoselectivity. Notably, the properties of a base have been shown to play a crucial role in the generation selectivity of this transformation. A novel base-mediated direct difluoroalkylation of 1,6-enynes involving a CF 2 radical process has been developed.
doi_str_mv 10.1039/c8cc03280g
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source Royal Society of Chemistry:Jisc Collections:Royal Society of Chemistry Read and Publish 2022-2024 (reading list)
subjects Chemical synthesis
Functional groups
Stereoselectivity
title Base promoted direct difunctionalization/cascade cyclization of 1,6-enynes
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