Synthesis and photodynamic effects of new porphyrin/4-oxoquinoline derivatives in the inactivation of

New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e . Singlet oxygen studies have demonstrated that all t...

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Published in:Photochemical & photobiological sciences 2019-08, Vol.18 (8), p.191-1922
Main Authors: Sagrillo, Fernanda Savacini, Dias, Cristina, Gomes, Ana T. P. C, Faustino, Maria A. F, Almeida, Adelaide, Gonçalves de Souza, Alan, Costa, Amanda Rodrigues Pinto, Boechat, Fernanda da Costa Santos, Bastos Vieira de Souza, Maria Cecília, Neves, Maria G. P. M. S, Cavaleiro, José A. S
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Summary:New porphyrin/4-oxoquinoline conjugates were synthesized from the Heck coupling reaction of a β-brominated porphyrin with 1-allyl-4-oxoquinoline derivatives, followed by demetallation and deprotection affording the promising photosensitizers 9a-e . Singlet oxygen studies have demonstrated that all the porphyrin/4-oxoquinoline conjugates 9a-e were capable of producing cytotoxic species and found to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy (aPDT) protocol. New porphyrin/4-oxoquinoline conjugates were synthesized and shown to be excellent photosensitizing agents in the inactivation of S. aureus by the antimicrobial photodynamic therapy protocol.
ISSN:1474-905X
1474-9092
DOI:10.1039/c9pp00102f