Nickel-catalyzed oxidative thiolation of α-amino carbonyl compounds with thiols

An efficient oxidative thiolation of α-amino carbonyl compounds with thiols by the catalysis of an Earth-abundant nickel salt is disclosed for the first time. A variety of alkyl thiols and (hetero)aryl thiols underwent the reaction well with α-amino ketones and an α-amino ester to produce the desire...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-03, Vol.22 (1), p.23-26
Main Authors: Li, Gaoqiang, Zhao, Xiaoqian, Zhang, Jiarui, Liu, Xue, Sun, Bangguo, Xu, Feng
Format: Article
Language:English
Subjects:
Carbonyl compounds
Carbonyls
Catalysis
Ketones
Nickel
Thiols
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Summary:An efficient oxidative thiolation of α-amino carbonyl compounds with thiols by the catalysis of an Earth-abundant nickel salt is disclosed for the first time. A variety of alkyl thiols and (hetero)aryl thiols underwent the reaction well with α-amino ketones and an α-amino ester to produce the desired α,α-aminothiocarbonyl compounds in good to excellent yields under ligand- and base-free conditions. An efficient Ni( ii )-catalyzed oxidative thiolation of α-amino ketones and ester with various thiols has been realized, providing a straightforward strategy to access α,α-aminothiocarbonyl compounds in good to excellent yields.
ISSN:1477-0520
1477-0539
DOI:10.1039/d3ob01825c