Co()-catalyzed regioselective benzannulation of substituted pyridones with 1,6-diynes dual C-H bond activation
A Co( iii )-catalyzed site-selective C5 and C6 benzannulation of substituted pyridones with 1,6-diynes via dual C-H bond activation has been reported. The scope of the benzannulation reaction was examined with various substituted 2-pyridyl pyridones and 1,6-diynes. The combination of cuprous acetate...
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Published in: | Chemical communications (Cambridge, England) England), 2024-08, Vol.6 (63), p.8296-8299 |
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Main Authors: | , |
Format: | Article |
Language: | |
Online Access: | Get full text |
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Summary: | A Co(
iii
)-catalyzed site-selective C5 and C6 benzannulation of substituted pyridones with 1,6-diynes
via
dual C-H bond activation has been reported. The scope of the benzannulation reaction was examined with various substituted 2-pyridyl pyridones and 1,6-diynes. The combination of cuprous acetate and silver carbonate plays a crucial role in the success of the reaction. A plausible reaction mechanism was proposed and supported by deuterium labelling studies and radical trapping experiments.
A cobalt(
iii
)-catalyzed C5/C6 benzannulation of substituted pyridones with 1,6-diynes
via
dual C-H bond activation has been demonstrated for the synthesis of various heterocyclic quinolinone molecules. |
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ISSN: | 1359-7345 1364-548X |
DOI: | 10.1039/d4cc01904k |