Body temperature protein X-ray crystallography at 37 °C: a rhenium protein complex seeking a physiological condition structure

The retention of the covalent binding of an organometalllic rhenium complex as a model for a technetium-99m imaging agent, to a protein at physiological body temperature 37 °C is described. Detailed structure comparisons are made to the related 100 K crystal structure. The generality of the need for...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-11, Vol.6 (95), p.143-1433
Main Authors: Jacobs, Francois J. F, Helliwell, John R, Brink, Alice
Format: Article
Language:English
Subjects:
Body temperature
Coordination Complexes - chemistry
Crystal structure
Crystallography
Crystallography, X-Ray
Lead compounds
Models, Molecular
Proteins
Rhenium
Rhenium - chemistry
Technetium
Technetium isotopes
Temperature
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Description
Summary:The retention of the covalent binding of an organometalllic rhenium complex as a model for a technetium-99m imaging agent, to a protein at physiological body temperature 37 °C is described. Detailed structure comparisons are made to the related 100 K crystal structure. The generality of the need for this sort of analytical procedure for guiding ligand lead compound discovery is emphasised. The retention of the covalent binding of an organometalllic rhenium complex to a protein at physiological body temperature (37 °C) is described and compared to the related 100 K crystal structure.
ISSN:1359-7345
1364-548X
1364-548X
DOI:10.1039/d4cc04245j