Radical alkylation of acrylamides with peroxides to access mono/dialkylated fused N-heterocycles

A simple mono/dialkylation of acrylamide derivatives was achieved, affording diverse mono/dialkylated benzo[4,5]imidazo[2,1- a ]isoquinolines or polycyclic coumarins with good substrate scope. This system used common peroxides as alkylating reagents. Meanwhile, a series of scaled-up reactions and me...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2024-12, Vol.22 (47), p.9184-9187
Main Authors: Fan, Jie, Yan, Qinqin, Wang, Xueli, Li, Lijun, Li, Zejiang
Format: Article
Language:English
Subjects:
Acrylamide
Alkylation
Cascade chemical reactions
Peroxides
Reagents
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Summary:A simple mono/dialkylation of acrylamide derivatives was achieved, affording diverse mono/dialkylated benzo[4,5]imidazo[2,1- a ]isoquinolines or polycyclic coumarins with good substrate scope. This system used common peroxides as alkylating reagents. Meanwhile, a series of scaled-up reactions and mechanistic explorations well demonstrated the application and reaction process of this cascade system. Radical alkylation of acrylamides with peroxides, which resulted in diverse mono/dialkylated polyheterocycles is reported.
ISSN:1477-0520
1477-0539
1477-0539
DOI:10.1039/d4ob01555j