Development of a specific fluorescent probe to detect advanced glycation end products (AGEs)

Advanced glycation end products (AGEs) play a pivotal role in the aging process, regarded as a hallmark of aging. Despite their significance, the absence of adequate monitoring tools has hindered the exploration of the relationship between AGEs and aging. Here, we present a novel AGE-selective probe...

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Bibliographic Details
Published in:Journal of materials chemistry. B, Materials for biology and medicine Materials for biology and medicine, 2024-06, Vol.12 (25), p.6155-6163
Main Authors: Cho, Heewon, Hong, Na-Kyeong, Yong, Insung, Kwon, Haw-Young, Kang, Nam-Young, Ciaramicoli, Larissa Miasiro, Kim, Pilnam, Chang, Young-Tae
Format: Article
Language:English
Subjects:
Advanced glycosylation end products
Age
Aging
Collagen - chemistry
Collagen - metabolism
Fluorescent Dyes - chemical synthesis
Fluorescent Dyes - chemistry
Fluorescent indicators
Glycation End Products, Advanced - analysis
Glycation End Products, Advanced - metabolism
Humans
Measurement methods
Molecular Structure
Optical Imaging
Ribose
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Summary:Advanced glycation end products (AGEs) play a pivotal role in the aging process, regarded as a hallmark of aging. Despite their significance, the absence of adequate monitoring tools has hindered the exploration of the relationship between AGEs and aging. Here, we present a novel AGE-selective probe, AGO, for the first time. AGO exhibited superior sensitivity in detecting AGEs compared to the conventional method of measuring autofluorescence from AGEs. Furthermore, we validated AGO's ability to detect AGEs based on kinetics, demonstrating a preference for ribose-derived AGEs. Lastly, AGO effectively visualized glycation products in a collagen-based mimicking model of glycation. We anticipate that this study will enhance the molecular tool sets available for comprehending the physiological processes of AGEs during aging. A novel fluorescent probe, AGO, systematically detects advanced glycation end products involved in aging.
ISSN:2050-750X
2050-7518
2050-7518
DOI:10.1039/d4tb00590b