Efficacy of preoperative nonsteroidal anti-inflammatory drug and the re-dilation technique in minimizing miosis after femtosecond laser in cataract surgery

• Published in: Arquivos brasileiros de oftalmologia 2019-03, Vol.82 (2), p.111-118
• Main Authors: Ventura, Bruna Vieira, Rabello, Laura Portela, Silvestre, Fernanda, Ventura, Marcelo Carvalho
• Format: Article
• Language: English
• Subjects: Aged; Aged, 80 and over; Anti-Inflammatory Agents, Non-Steroidal - therapeutic use; Female; Flurbiprofen - therapeutic use; Humans; Intraocular Pressure; Intraoperative Complications - prevention & control; Laser Therapy - methods; Lasers; Male; Middle Aged; Miosis - etiology; Miosis - pathology; Miosis - prevention & control; Mydriatics - therapeutic use; OPHTHALMOLOGY; Phacoemulsification - adverse effects; Phacoemulsification - methods; Phenylephrine - therapeutic use; Preoperative Period; Pupil - drug effects; Reproducibility of Results; Retrospective Studies; Statistics, Nonparametric; Treatment Outcome; Tropicamide - therapeutic use
• ISSN: 0004-2749; 1678-2925; 1678-2925
• DOI: 10.5935/0004-2749.20190025

To assess the efficacy of using a nonste-roidal anti-inflammatory drug preoperatively and of applying the re-dilation technique when necessary to minimize pupil size variation when comparing the degree of mydriasis before femtosecond laser pretreatment with that at the beginning of phacoemulsification. This retrospective study included patients who underwent cataract surgery using the LenSx (Alcon Laboratories, Inc., Fort Worth, TX). Our routine dilating regimen with flurbiprofen, tropicamide, and phenylephrine was used. The re-dilation technique was applied on eyes that manifested with a pupillary diameter that was smaller than the programmed capsulotomy diameter after laser pretreatment. The technique consists of overcoming pupillary contraction by instilling tropicamide and phenylephrine before phacoemulsification. Pupil size was assessed before femtosecond laser application and at the beginning of phacoemulsification. Seventy-five eyes (70 patients) were included. Nine (12%) eyes underwent the re-dilation technique. There was no significant difference in mean pupillary diameter and mean pupillary area between the two studied surgical time points (p=0.412 and 0.437, respectively). The overall pupillary area constriction was 2.4 mm2. Immediately before opening the wounds for phacoemulsification, none of the eyes presented with a pupillary diameter 6 mm. Preoperative administration of nonsteroidal anti-inflammatory drug and the re-dilation technique resulted in no significant pupil size variation in eyes that were pretreated with the femtosecond laser, when comparing the measurements made before the laser application and at the beginning of phacoemulsification. This approach can avoid the need to proceed with cataract extraction with a constricted pupil.