Acanthosis nigricans and insulin resistance in overweight children and adolescents

• Published in: Anais brasileiros de dermatología 2012-07, Vol.87 (4), p.531-537
• Main Authors: Kluczynik, Caroline Evelin Nascimento, Mariz, Larissa Soares, Souza, Larissa Camila Ferreira, Solano, Gabriela Beserra, Albuquerque, Fernanda Cruz de Lira, Medeiros, Carla Campos Muniz
• Format: Article
• Language: English
• Subjects: Acanthosis Nigricans - blood; Acanthosis Nigricans - complications; Acanthosis Nigricans - physiopathology; Adolescent; Blood Glucose - analysis; Body Mass Index; Child; Child, Preschool; Cholesterol, HDL - blood; Cross-Sectional Studies; DERMATOLOGY; Female; Homeostasis; Humans; Infant; Insulin - blood; Insulin Resistance - physiology; Male; Metabolic Syndrome - diagnosis; Metabolic Syndrome - etiology; Metabolic Syndrome - physiopathology; Overweight - blood; Overweight - complications; Triglycerides - blood; Young Adult
• ISSN: 0365-0596; 1806-4841; 1806-4841; 0365-0596
• DOI: 10.1590/S0365-05962012000400002

Studies have suggested an association between the presence of acanthosis nigricans (AN) and the development of diabetes. To investigate the association between AN and insulin resistance (IR) in overweight children and adolescents receiving care at the Center for Childhood Obesity, Campina Grande, PB. This cross-sectional study was conducted between April 2009 and April 2010 including 194 individuals of 2 to 18 years of age receiving care within the Brazilian national health network. The presence of acanthosis nigricans was verified and anthropometric measurements were taken. The following tests were performed: insulin, triglycerides, HDL-cholesterol, glucose and homeostasis model of assessment - insulin resistance (HOMA-IR). Statistical analyses were performed using the SPSS software program, version 17.0. There was a greater prevalence of females (66%), brown-skinned individuals (63.4%), adolescents (61.3%) and severely obese individuals (66.5%). Acanthosis nigricans was identified in 58.2% and IR in 42.7% of the participants. Acanthosis nigricans was associated with being non-white (p = 0.003), with being an adolescent (p = 0.003) and with IR (p = 0.001). Non-white individuals, adolescents and those with insulin resistance were 5.4, 2.47 and 2.66 times more likely to have acanthosis nigricans, respectively. The results of this study indicate a need to train healthcare professionals to identify acanthosis nigricans, since this condition is associated with IR. Identifying acanthosis nigricans in childhood permits the safe and timely treatment of cardiometabolic disorders through careful monitoring and appropriate treatment.