The prevalence of psychopathology in offspring of bipolar women from a Brazilian tertiary center

No previous study has assessed the occurrence of psychopathology in offspring of bipolar women from South America. The objective of this study was to assess the prevalence of psychopathology in offspring of bipolar mothers from Brazil compared with two control groups. Children and adolescents aged 6...

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Bibliographic Details
Published in:Revista brasileira de psiquiatria 2009-09, Vol.31 (3), p.240-246
Main Authors: Petresco, Sandra, Gutt, Elisa Kijner, Krelling, Renata, Lotufo Neto, Francisco, Rohde, Luis Augusto Paim, Moreno, Ricardo Alberto
Format: Article
Language:English
Subjects:
Adolescent
Bipolar Disorder - psychology
Brazil - epidemiology
Case-Control Studies
Child
Child of Impaired Parents - psychology
Comorbidity
Female
Humans
Intelligence Tests
Male
Mental Disorders - epidemiology
Mothers - psychology
Prevalence
Psychiatric Status Rating Scales
PSYCHIATRY
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Summary:No previous study has assessed the occurrence of psychopathology in offspring of bipolar women from South America. The objective of this study was to assess the prevalence of psychopathology in offspring of bipolar mothers from Brazil compared with two control groups. Children and adolescents aged 6 to 18 years of bipolar disorders mothers (n = 43), mothers with other mild to moderate mental disorders (n = 53) and mothers without any psychiatric disorder (n = 53) were evaluated using the Kiddie Schedule for Affective Disorders and Schizophrenia present and lifetime version, the Child Behavior Checklist and the Youth Self-Report. Raters were blind to the mothers' diagnoses, who were interviewed by means of the Structured Clinical Interview. Bipolar offspring had twice the chance of having one or more lifetime Axis I diagnoses [prevalence ratio = 2.11 (95% CI: 1.30-3.42) and p = 0.003] and 2.8 higher risk of having a lifetime anxiety disorder [prevalence ratio = 2.83 (95% CI: 1.39-5.78) e p = 0.004] than the offspring of mothers with no mental disorder. In addition, significantly higher scores on Child Behavior Checklist thought problems and Youth Self-Report social problems, as well as anxiety/depression and internalizing problems were observed. Our results confirm previous findings suggesting higher psychiatric problems in offspring of bipolar mothers and extend them to the Brazilian society.
ISSN:1516-4446
1809-452X
1516-4446
DOI:10.1590/S1516-44462009000300009