Short-term immunosuppressive therapy does not affect the density of the pre-existing bone around titanium implants placed in rabbits

The aim of this study was to evaluate the influence of the administration and withdrawal of cyclosporin A/nifedipine on the bone density in a lateral area adjacent to implants placed in rabbits. Two screw-type titanium implants were placed bilaterally in twenty-eight New Zealand rabbits. The animals...

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Published in:Pesquisa odontológica brasileira 2003-12, Vol.17 (4), p.362-366
Main Authors: Duarte, Poliana Mendes, Nogueira Filho, Getúlio Rocha, Sallum, Enilson Antônio, Sallum, Antonio Wilson, Nociti Júnior, Francisco Humberto
Format: Article
Language:English
Subjects:
Analysis of Variance
Animals
Bone Density - drug effects
Calcium Channel Blockers - administration & dosage
Cyclosporine - administration & dosage
Cyclosporine - adverse effects
Dental Implantation, Endosseous - methods
Dental Implants
DENTISTRY, ORAL SURGERY & MEDICINE
Drug Combinations
Immunosuppressive Agents - administration & dosage
Implants, Experimental
Male
Nifedipine - administration & dosage
Osseointegration - physiology
Rabbits
Statistics, Nonparametric
Tibia
Titanium - therapeutic use
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Summary:The aim of this study was to evaluate the influence of the administration and withdrawal of cyclosporin A/nifedipine on the bone density in a lateral area adjacent to implants placed in rabbits. Two screw-type titanium implants were placed bilaterally in twenty-eight New Zealand rabbits. The animals were assigned to one of the following groups and received daily subcutaneous injections for 14 days: Groups A and C: vehicle (dimethyl sulfoxide); Groups B and D: CsA (10 mg/kg) plus nifedipine (50 mg/kg). The animals in Groups A and B were sacrificed 14 days postoperatively and, in Groups C and D, 42 days postoperatively. After sacrifice, the tibiae were removed and undecalcified sections were obtained. Bone density was obtained in a 500 mm-wide zone lateral to the implant surface. Intergroup analysis showed no significant difference (p > 0.05) in the degree of bone density between control and test groups either on day 14 or on day 42. Thus, it appears that a short-term immunosuppressive therapy may not present a negative influence on the density of the pre-existing bone around titanium implants placed in rabbits.
ISSN:1517-7491
1517-7491
DOI:10.1590/S1517-74912003000400012