Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus

Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant...

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Published in:Revista Brasileira de Saúde Materno Infantil 2017-12, Vol.17 (4), p.833-842
Main Authors: Oliveira, Vanessa Marcon de, Figueiró-Filho, Ernesto Antonio, Ferreira, Cristiane Munaretto, Pereira, Erica Freire de Vasconcelos
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Language:English
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Antiphospholipid syndrome
hematologic
PEDIATRICS
Pregnancy complications
Systemic lupus erythematosus
Thrombophilia
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description Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant women without known disease and with at least one previous pregnancy (control group). The presence of antiphospholipid antibodies and hereditary thrombophilia were examined in both groups. We used the y2 Test with Yates correction or Fisher's Exact Test to verify the associations and calculate the relative risk. Results: thrombophilia was present in 72.0% of pregnant women with SLE and in 6.0% of patients in the control group. A significant association was found between the presence of SLE and serum markers for hereditary thrombophilia / antiphospholipid antibodies (p
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Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant women without known disease and with at least one previous pregnancy (control group). The presence of antiphospholipid antibodies and hereditary thrombophilia were examined in both groups. We used the y2 Test with Yates correction or Fisher's Exact Test to verify the associations and calculate the relative risk. Results: thrombophilia was present in 72.0% of pregnant women with SLE and in 6.0% of patients in the control group. A significant association was found between the presence of SLE and serum markers for hereditary thrombophilia / antiphospholipid antibodies (p&lt;0.05). The relative risks for antiphospholipid antibodies were 13.20 (ICR95%= 1.81 - 96.46) in pregnant women with SLE, 7.26 (CI95%= 1.77 - 29.86) for the presence of serum markers of hereditary thrombophilia and 7.92 (CI95%= 2.62 - 3.94) for the presence of hereditary thrombophilia and/or antiphospholipid antibodies. Conclusions: the identification of markers for hereditary and/or acquired thrombophilia in pregnant women with lupus may be clinically useful to determine which patients have a higher risk of obstetric complications. Resumo Objetivos: determinar a frequência e a associação ente LES em gestantes e a ocorrência de marcadores séricos para trombofilias hereditárias e adquiridas no grupo de gestantes estudadas. Métodos: foi realizado estudo caso-controle com 25 gestantes portadoras de Lúpus Eritematoso Sistêmico (grupo estudo) e 32 gestantes sem doença conhecida, com pelo menos uma gestação anterior (grupo controle). A presença de anticorpos antifosfolípides e trombofilia hereditária foi examinada em ambos os grupos. Utilizamos o Teste y2 com correção de Yates ou Teste Exato de Fisher para verificar as associações e calcular o risco relativo. Resultados: verificou-se a presença de trombofilias em 72,0% das gestantes portadoras de LES e em 6,0% das pacientes do grupo controle. Encontrou-se significante associação entre a presença de LES em gestantes e marcadores séricos para trombofilias hereditárias/anticorpos antifosfolípides (p&lt;0,05). Identificou-se risco relativo para presença de anticorpos antifosfolípides de 13,20 (1,81&lt;RR&lt;96,46) em gestantes portadoras de LES, 7.26 (IC95%=1.77-29.86) para presença de marcadores séricos de trombofilias hereditárias e de 7.92 (IC95%= 2.62 - 23.94) considerando a presença de trombofilias hereditárias e/ou presença de anticorpos antifosfolípides. Conclusões: a identificação de marcadores para trombofilia hereditária e/ou adquirida em gestantes com lúpus pode ser clinicamente útil para determinar quais pacientes apresentam maior risco de complicações obstétricas.</description><identifier>ISSN: 1806-9304</identifier><identifier>EISSN: 1806-9304</identifier><identifier>DOI: 10.1590/1806-93042017000400012</identifier><language>eng</language><publisher>Instituto de Medicina Integral Prof. Fernando Figueira</publisher><subject>Antiphospholipid syndrome ; hematologic ; PEDIATRICS ; Pregnancy complications ; Systemic lupus erythematosus ; Thrombophilia</subject><ispartof>Revista Brasileira de Saúde Materno Infantil, 2017-12, Vol.17 (4), p.833-842</ispartof><rights>This work is licensed under a Creative Commons Attribution 4.0 International License.</rights><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c2002-ee4a110059eb004a36ae1dd53a51f0847a620cf33ee950fd42c51785c0b735c53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,24150,27924,27925</link.rule.ids></links><search><creatorcontrib>Oliveira, Vanessa Marcon de</creatorcontrib><creatorcontrib>Figueiró-Filho, Ernesto Antonio</creatorcontrib><creatorcontrib>Ferreira, Cristiane Munaretto</creatorcontrib><creatorcontrib>Pereira, Erica Freire de Vasconcelos</creatorcontrib><title>Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus</title><title>Revista Brasileira de Saúde Materno Infantil</title><addtitle>Rev. Bras. Saude Mater. Infant</addtitle><description>Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant women without known disease and with at least one previous pregnancy (control group). The presence of antiphospholipid antibodies and hereditary thrombophilia were examined in both groups. We used the y2 Test with Yates correction or Fisher's Exact Test to verify the associations and calculate the relative risk. Results: thrombophilia was present in 72.0% of pregnant women with SLE and in 6.0% of patients in the control group. A significant association was found between the presence of SLE and serum markers for hereditary thrombophilia / antiphospholipid antibodies (p&lt;0.05). The relative risks for antiphospholipid antibodies were 13.20 (ICR95%= 1.81 - 96.46) in pregnant women with SLE, 7.26 (CI95%= 1.77 - 29.86) for the presence of serum markers of hereditary thrombophilia and 7.92 (CI95%= 2.62 - 3.94) for the presence of hereditary thrombophilia and/or antiphospholipid antibodies. Conclusions: the identification of markers for hereditary and/or acquired thrombophilia in pregnant women with lupus may be clinically useful to determine which patients have a higher risk of obstetric complications. Resumo Objetivos: determinar a frequência e a associação ente LES em gestantes e a ocorrência de marcadores séricos para trombofilias hereditárias e adquiridas no grupo de gestantes estudadas. Métodos: foi realizado estudo caso-controle com 25 gestantes portadoras de Lúpus Eritematoso Sistêmico (grupo estudo) e 32 gestantes sem doença conhecida, com pelo menos uma gestação anterior (grupo controle). A presença de anticorpos antifosfolípides e trombofilia hereditária foi examinada em ambos os grupos. Utilizamos o Teste y2 com correção de Yates ou Teste Exato de Fisher para verificar as associações e calcular o risco relativo. Resultados: verificou-se a presença de trombofilias em 72,0% das gestantes portadoras de LES e em 6,0% das pacientes do grupo controle. Encontrou-se significante associação entre a presença de LES em gestantes e marcadores séricos para trombofilias hereditárias/anticorpos antifosfolípides (p&lt;0,05). Identificou-se risco relativo para presença de anticorpos antifosfolípides de 13,20 (1,81&lt;RR&lt;96,46) em gestantes portadoras de LES, 7.26 (IC95%=1.77-29.86) para presença de marcadores séricos de trombofilias hereditárias e de 7.92 (IC95%= 2.62 - 23.94) considerando a presença de trombofilias hereditárias e/ou presença de anticorpos antifosfolípides. Conclusões: a identificação de marcadores para trombofilia hereditária e/ou adquirida em gestantes com lúpus pode ser clinicamente útil para determinar quais pacientes apresentam maior risco de complicações obstétricas.</description><subject>Antiphospholipid syndrome</subject><subject>hematologic</subject><subject>PEDIATRICS</subject><subject>Pregnancy complications</subject><subject>Systemic lupus erythematosus</subject><subject>Thrombophilia</subject><issn>1806-9304</issn><issn>1806-9304</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>DOA</sourceid><recordid>eNplUdFqAjEQPEoLFesvlPyAdpNccnePRWwrCD7YPodc3Gisd5HkDvHvG2uxhT4su-wyw8xslj1SmFBRwRMtQY4rDjkDWgBAnoqym2xwPdz-me-zUYyuBhCCclbBIFuuMPQNaXT4xBBJtw2-qf1h6_ZOE9eSQ8BNq9uOHH2DLTm6bktWp9hh4wxZ9Ic-klk4dVtsdOdjHx-yO6v3EUc_fZh9vMzep2_jxfJ1Pn1ejA0DYGPEXFOadFSY1OSaS410vRZcC2qhzAstGRjLOWIlwK5zZgQtSmGgLrgwgg-z-YV37fVOHYJLDk7Ka6e-Fz5slA6dM3tUyagsyyJP-CKXEmoLopYWWWFLa1AmrsmFKxqHe692vg9tEq9WVNBK8ZJVv-mWnCeAvABM8DEGtFcBFNT5LeqcuPr3Fv4FK-d8tg</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Oliveira, Vanessa Marcon de</creator><creator>Figueiró-Filho, Ernesto Antonio</creator><creator>Ferreira, Cristiane Munaretto</creator><creator>Pereira, Erica Freire de Vasconcelos</creator><general>Instituto de Medicina Integral Prof. Fernando Figueira</general><general>Instituto Materno Infantil de Pernambuco</general><scope>AAYXX</scope><scope>CITATION</scope><scope>GPN</scope><scope>DOA</scope></search><sort><creationdate>201712</creationdate><title>Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus</title><author>Oliveira, Vanessa Marcon de ; Figueiró-Filho, Ernesto Antonio ; Ferreira, Cristiane Munaretto ; Pereira, Erica Freire de Vasconcelos</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2002-ee4a110059eb004a36ae1dd53a51f0847a620cf33ee950fd42c51785c0b735c53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Antiphospholipid syndrome</topic><topic>hematologic</topic><topic>PEDIATRICS</topic><topic>Pregnancy complications</topic><topic>Systemic lupus erythematosus</topic><topic>Thrombophilia</topic><toplevel>online_resources</toplevel><creatorcontrib>Oliveira, Vanessa Marcon de</creatorcontrib><creatorcontrib>Figueiró-Filho, Ernesto Antonio</creatorcontrib><creatorcontrib>Ferreira, Cristiane Munaretto</creatorcontrib><creatorcontrib>Pereira, Erica Freire de Vasconcelos</creatorcontrib><collection>CrossRef</collection><collection>SciELO</collection><collection>DOAJ Directory of Open Access Journals</collection><jtitle>Revista Brasileira de Saúde Materno Infantil</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Oliveira, Vanessa Marcon de</au><au>Figueiró-Filho, Ernesto Antonio</au><au>Ferreira, Cristiane Munaretto</au><au>Pereira, Erica Freire de Vasconcelos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus</atitle><jtitle>Revista Brasileira de Saúde Materno Infantil</jtitle><addtitle>Rev. Bras. Saude Mater. Infant</addtitle><date>2017-12</date><risdate>2017</risdate><volume>17</volume><issue>4</issue><spage>833</spage><epage>842</epage><pages>833-842</pages><issn>1806-9304</issn><eissn>1806-9304</eissn><abstract>Abstract Objectives: to determine the frequency of serum markers for hereditary and acquired thrombophilia and their association with pregnancy in women with Systemic Lupus Erythematosus (SLE). Methods: a case-control study was conducted among 25 pregnant women with SLE (study group) and 32 pregnant women without known disease and with at least one previous pregnancy (control group). The presence of antiphospholipid antibodies and hereditary thrombophilia were examined in both groups. We used the y2 Test with Yates correction or Fisher's Exact Test to verify the associations and calculate the relative risk. Results: thrombophilia was present in 72.0% of pregnant women with SLE and in 6.0% of patients in the control group. A significant association was found between the presence of SLE and serum markers for hereditary thrombophilia / antiphospholipid antibodies (p&lt;0.05). The relative risks for antiphospholipid antibodies were 13.20 (ICR95%= 1.81 - 96.46) in pregnant women with SLE, 7.26 (CI95%= 1.77 - 29.86) for the presence of serum markers of hereditary thrombophilia and 7.92 (CI95%= 2.62 - 3.94) for the presence of hereditary thrombophilia and/or antiphospholipid antibodies. Conclusions: the identification of markers for hereditary and/or acquired thrombophilia in pregnant women with lupus may be clinically useful to determine which patients have a higher risk of obstetric complications. Resumo Objetivos: determinar a frequência e a associação ente LES em gestantes e a ocorrência de marcadores séricos para trombofilias hereditárias e adquiridas no grupo de gestantes estudadas. Métodos: foi realizado estudo caso-controle com 25 gestantes portadoras de Lúpus Eritematoso Sistêmico (grupo estudo) e 32 gestantes sem doença conhecida, com pelo menos uma gestação anterior (grupo controle). A presença de anticorpos antifosfolípides e trombofilia hereditária foi examinada em ambos os grupos. Utilizamos o Teste y2 com correção de Yates ou Teste Exato de Fisher para verificar as associações e calcular o risco relativo. Resultados: verificou-se a presença de trombofilias em 72,0% das gestantes portadoras de LES e em 6,0% das pacientes do grupo controle. Encontrou-se significante associação entre a presença de LES em gestantes e marcadores séricos para trombofilias hereditárias/anticorpos antifosfolípides (p&lt;0,05). Identificou-se risco relativo para presença de anticorpos antifosfolípides de 13,20 (1,81&lt;RR&lt;96,46) em gestantes portadoras de LES, 7.26 (IC95%=1.77-29.86) para presença de marcadores séricos de trombofilias hereditárias e de 7.92 (IC95%= 2.62 - 23.94) considerando a presença de trombofilias hereditárias e/ou presença de anticorpos antifosfolípides. Conclusões: a identificação de marcadores para trombofilia hereditária e/ou adquirida em gestantes com lúpus pode ser clinicamente útil para determinar quais pacientes apresentam maior risco de complicações obstétricas.</abstract><pub>Instituto de Medicina Integral Prof. Fernando Figueira</pub><doi>10.1590/1806-93042017000400012</doi><tpages>10</tpages><oa>free_for_read</oa></addata></record>
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subjects Antiphospholipid syndrome
hematologic
PEDIATRICS
Pregnancy complications
Systemic lupus erythematosus
Thrombophilia
title Serum markers thrombophilia in pregnant women with Systemic Lupus Erythematosus
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