γ-Lactones Upon Double Nucleophilic Additions of Bis(TMS)Ketene Acetals to Π-systems and Access to New-towards Cancer Cells Cytotoxic-Endoperoxide Lactones

Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transforme...

Full description

Saved in:
Bibliographic Details
Published in:Journal of the Mexican Chemical Society 2008-06, Vol.52 (2), p.145-174
Main Authors: Rudler, Henri, Aldeco-Pérez, Eugenia, Parlier, Andrée, Álvarez, Cecilio, Chaquin, Patrick, Herson, Patrick, Toscano, Alfredo, Ramírez-Apan, María-Teresa
Format: Article
Language:eng ; por
Subjects:
Chemistry, Multidisciplinary
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
cited_by
cites
container_end_page 174
container_issue 2
container_start_page 145
container_title Journal of the Mexican Chemical Society
container_volume 52
creator Rudler, Henri
Aldeco-Pérez, Eugenia
Parlier, Andrée
Álvarez, Cecilio
Chaquin, Patrick
Herson, Patrick
Toscano, Alfredo
Ramírez-Apan, María-Teresa
description Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transformed either in arylpropionic acids or in conjugated ketones and more interestingly, they reacted with oxygen to give new highly active cytotoxic endoperoxide lactones. Unfortunately, in the second case, no further functionalization could be achieved up to now.
format article
fullrecord <record><control><sourceid>scielo</sourceid><recordid>TN_cdi_scielo_journals_S1870_249X2008000200009</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><scielo_id>S1870_249X2008000200009</scielo_id><sourcerecordid>S1870_249X2008000200009</sourcerecordid><originalsourceid>FETCH-LOGICAL-s194t-f917928eb80193f8b0e23e328f2ab9d71d067fa5e8c4d0a582cf31df337036fa3</originalsourceid><addsrcrecordid>eNo1UMtOAjEUnYUmIvoPXeqipo-BaZc44iMiLoDEHem0t7FkbMm0BPkYE__B_-CbLD5W5yYn97yOih4VFcGslC8nxWmMK0KGFa1or_jYf-GJ0il4iGixDh7dhE3TAppudAth_epap9HIGJdc8BEFi65dvJg_zS4fIYEHNNKQVBtRCmj_ieMuJniLSHmTGQ3xh5jCFqewVZ2JqFZeQ4dqaPNTvUshhXen8dibsIYu3wbQf6Kz4thmbTj_w36xuB3P63s8eb57qEcTHKksE7aSVpIJaAShklvREGAcOBOWqUaaippc16oBCF0aogaCacupsZxXhA-t4v3i6lc3agdtWK7CpvPZcDk77LY87MYIEYSQDIRI_g0yy2lh</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype></control><display><type>article</type><title>γ-Lactones Upon Double Nucleophilic Additions of Bis(TMS)Ketene Acetals to Π-systems and Access to New-towards Cancer Cells Cytotoxic-Endoperoxide Lactones</title><source>Free Full-Text Journals in Chemistry</source><creator>Rudler, Henri ; Aldeco-Pérez, Eugenia ; Parlier, Andrée ; Álvarez, Cecilio ; Chaquin, Patrick ; Herson, Patrick ; Toscano, Alfredo ; Ramírez-Apan, María-Teresa</creator><creatorcontrib>Rudler, Henri ; Aldeco-Pérez, Eugenia ; Parlier, Andrée ; Álvarez, Cecilio ; Chaquin, Patrick ; Herson, Patrick ; Toscano, Alfredo ; Ramírez-Apan, María-Teresa</creatorcontrib><description>Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transformed either in arylpropionic acids or in conjugated ketones and more interestingly, they reacted with oxygen to give new highly active cytotoxic endoperoxide lactones. Unfortunately, in the second case, no further functionalization could be achieved up to now.</description><identifier>ISSN: 1870-249X</identifier><language>eng ; por</language><publisher>Sociedad Química de México A.C</publisher><subject>Chemistry, Multidisciplinary</subject><ispartof>Journal of the Mexican Chemical Society, 2008-06, Vol.52 (2), p.145-174</ispartof><rights>This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 International License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,776,780,881</link.rule.ids></links><search><creatorcontrib>Rudler, Henri</creatorcontrib><creatorcontrib>Aldeco-Pérez, Eugenia</creatorcontrib><creatorcontrib>Parlier, Andrée</creatorcontrib><creatorcontrib>Álvarez, Cecilio</creatorcontrib><creatorcontrib>Chaquin, Patrick</creatorcontrib><creatorcontrib>Herson, Patrick</creatorcontrib><creatorcontrib>Toscano, Alfredo</creatorcontrib><creatorcontrib>Ramírez-Apan, María-Teresa</creatorcontrib><title>γ-Lactones Upon Double Nucleophilic Additions of Bis(TMS)Ketene Acetals to Π-systems and Access to New-towards Cancer Cells Cytotoxic-Endoperoxide Lactones</title><title>Journal of the Mexican Chemical Society</title><addtitle>J. Mex. Chem. Soc</addtitle><description>Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transformed either in arylpropionic acids or in conjugated ketones and more interestingly, they reacted with oxygen to give new highly active cytotoxic endoperoxide lactones. Unfortunately, in the second case, no further functionalization could be achieved up to now.</description><subject>Chemistry, Multidisciplinary</subject><issn>1870-249X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2008</creationdate><recordtype>article</recordtype><recordid>eNo1UMtOAjEUnYUmIvoPXeqipo-BaZc44iMiLoDEHem0t7FkbMm0BPkYE__B_-CbLD5W5yYn97yOih4VFcGslC8nxWmMK0KGFa1or_jYf-GJ0il4iGixDh7dhE3TAppudAth_epap9HIGJdc8BEFi65dvJg_zS4fIYEHNNKQVBtRCmj_ieMuJniLSHmTGQ3xh5jCFqewVZ2JqFZeQ4dqaPNTvUshhXen8dibsIYu3wbQf6Kz4thmbTj_w36xuB3P63s8eb57qEcTHKksE7aSVpIJaAShklvREGAcOBOWqUaaippc16oBCF0aogaCacupsZxXhA-t4v3i6lc3agdtWK7CpvPZcDk77LY87MYIEYSQDIRI_g0yy2lh</recordid><startdate>20080601</startdate><enddate>20080601</enddate><creator>Rudler, Henri</creator><creator>Aldeco-Pérez, Eugenia</creator><creator>Parlier, Andrée</creator><creator>Álvarez, Cecilio</creator><creator>Chaquin, Patrick</creator><creator>Herson, Patrick</creator><creator>Toscano, Alfredo</creator><creator>Ramírez-Apan, María-Teresa</creator><general>Sociedad Química de México A.C</general><scope>GPN</scope></search><sort><creationdate>20080601</creationdate><title>γ-Lactones Upon Double Nucleophilic Additions of Bis(TMS)Ketene Acetals to Π-systems and Access to New-towards Cancer Cells Cytotoxic-Endoperoxide Lactones</title><author>Rudler, Henri ; Aldeco-Pérez, Eugenia ; Parlier, Andrée ; Álvarez, Cecilio ; Chaquin, Patrick ; Herson, Patrick ; Toscano, Alfredo ; Ramírez-Apan, María-Teresa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-s194t-f917928eb80193f8b0e23e328f2ab9d71d067fa5e8c4d0a582cf31df337036fa3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng ; por</language><creationdate>2008</creationdate><topic>Chemistry, Multidisciplinary</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Rudler, Henri</creatorcontrib><creatorcontrib>Aldeco-Pérez, Eugenia</creatorcontrib><creatorcontrib>Parlier, Andrée</creatorcontrib><creatorcontrib>Álvarez, Cecilio</creatorcontrib><creatorcontrib>Chaquin, Patrick</creatorcontrib><creatorcontrib>Herson, Patrick</creatorcontrib><creatorcontrib>Toscano, Alfredo</creatorcontrib><creatorcontrib>Ramírez-Apan, María-Teresa</creatorcontrib><collection>SciELO</collection><jtitle>Journal of the Mexican Chemical Society</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Rudler, Henri</au><au>Aldeco-Pérez, Eugenia</au><au>Parlier, Andrée</au><au>Álvarez, Cecilio</au><au>Chaquin, Patrick</au><au>Herson, Patrick</au><au>Toscano, Alfredo</au><au>Ramírez-Apan, María-Teresa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>γ-Lactones Upon Double Nucleophilic Additions of Bis(TMS)Ketene Acetals to Π-systems and Access to New-towards Cancer Cells Cytotoxic-Endoperoxide Lactones</atitle><jtitle>Journal of the Mexican Chemical Society</jtitle><addtitle>J. Mex. Chem. Soc</addtitle><date>2008-06-01</date><risdate>2008</risdate><volume>52</volume><issue>2</issue><spage>145</spage><epage>174</epage><pages>145-174</pages><issn>1870-249X</issn><abstract>Arenechromium and cycloheptatrienechromium complexes react with (TMS)ketene acetals to give upon a double nucleophilic addition either diene-lactones or cyclohexenone-lactones. In the first case, the scope of the reaction and the stability of the dienes were examined: they could be easily transformed either in arylpropionic acids or in conjugated ketones and more interestingly, they reacted with oxygen to give new highly active cytotoxic endoperoxide lactones. Unfortunately, in the second case, no further functionalization could be achieved up to now.</abstract><pub>Sociedad Química de México A.C</pub><tpages>30</tpages><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1870-249X
ispartof Journal of the Mexican Chemical Society, 2008-06, Vol.52 (2), p.145-174
issn 1870-249X
language eng ; por
recordid cdi_scielo_journals_S1870_249X2008000200009
source Free Full-Text Journals in Chemistry
subjects Chemistry, Multidisciplinary
title γ-Lactones Upon Double Nucleophilic Additions of Bis(TMS)Ketene Acetals to Π-systems and Access to New-towards Cancer Cells Cytotoxic-Endoperoxide Lactones
url http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-29T02%3A40%3A57IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-scielo&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=%CE%B3-Lactones%20Upon%20Double%20Nucleophilic%20Additions%20of%20Bis(TMS)Ketene%20Acetals%20to%20%CE%A0-systems%20and%20Access%20to%20New-towards%20Cancer%20Cells%20Cytotoxic-Endoperoxide%20Lactones&rft.jtitle=Journal%20of%20the%20Mexican%20Chemical%20Society&rft.au=Rudler,%20Henri&rft.date=2008-06-01&rft.volume=52&rft.issue=2&rft.spage=145&rft.epage=174&rft.pages=145-174&rft.issn=1870-249X&rft_id=info:doi/&rft_dat=%3Cscielo%3ES1870_249X2008000200009%3C/scielo%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-s194t-f917928eb80193f8b0e23e328f2ab9d71d067fa5e8c4d0a582cf31df337036fa3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_id=info:pmid/&rft_scielo_id=S1870_249X2008000200009&rfr_iscdi=true