Cellular and molecular pathways of structural damage in rheumatoid arthritis

Structural damage of cartilage and bone tissue is a hallmark of rheumatoid arthritis (RA). The resulting joint destruction constitutes one of the major disease consequences for patients and creates a significant burden for the society. The main cells executing bone and cartilage degradation are oste...

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Bibliographic Details
Published in:	Seminars in immunopathology 2017-06, Vol.39 (4), p.355-363
Main Authors:	Harre, Ulrike, Schett, Georg
Format:	Article
Language:	English
Subjects:	Animals Arthritis, Rheumatoid - etiology Arthritis, Rheumatoid - metabolism Arthritis, Rheumatoid - pathology Autoantibodies Autoantibodies - immunology Biomedical and Life Sciences Biomedicine Bone and Bones - immunology Bone and Bones - metabolism Bone and Bones - pathology Cartilage Cartilage - immunology Cartilage - metabolism Cartilage - pathology Chondrocytes Chondrocytes - metabolism Cytokines Cytokines - metabolism Fibroblasts Fibroblasts - metabolism Genetic transformation Humans Immune system Immunology Inflammation Inflammation Mediators - metabolism Internal Medicine Joint Capsule - immunology Joint Capsule - metabolism Joint Capsule - pathology Joint diseases Osteoblasts Osteoclasts Osteoclasts - immunology Osteoclasts - metabolism Review Rheumatoid arthritis Synoviocytes
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