GlyT1 Inhibition by NFPS Promotes Neuroprotection in Amyloid-β-Induced Alzheimer’s Disease Animal Model

Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by the accumulation of amyloid-β, leading to N-methyl-D-aspartate (NMDA) receptor-dependent synaptic depression, spine elimination, and memory deficits. Glycine transporter type 1 (GlyT1) modulates glutamatergic neurotransmission...

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Published in:	Neurochemical research 2024-09, Vol.49 (9), p.2535-2555
Main Authors:	Oliveira-Lima, Onésia Cristina, de Carvalho, Gustavo Almeida, do Prado Assunção, Leandro, Bailão, Alexandre Melo, Ulrich, Henning, Marques, Bruno Lemes, de Oliveira, Antônio Carlos Pinheiro, Gomez, Renato Santiago, Pinto, Mauro Cunha Xavier
Format:	Article
Language:	English
Subjects:	Alzheimer Disease - chemically induced Alzheimer Disease - drug therapy Alzheimer Disease - metabolism Alzheimer Disease - prevention & control Alzheimer's disease Amyloid beta-Peptides - metabolism Animal diseases Animal models Animals Biochemistry Biomedical and Life Sciences Biomedicine Brain-derived neurotrophic factor Ca2+/calmodulin-dependent protein kinase IV Cell Biology Cognitive tasks Cyclic AMP response element-binding protein Damage Disease Models, Animal Dopamine receptors Glutamate receptors Glutamatergic transmission Glutamic acid receptors (ionotropic) Glycine Glycine Plasma Membrane Transport Proteins - antagonists & inhibitors Glycine Plasma Membrane Transport Proteins - metabolism Glycine transporter Glycolysis Hippocampus Hippocampus - drug effects Hippocampus - metabolism Injection Long term memory Long-term potentiation Male Memory Memory tasks Mice Mice, Inbred C57BL N-Methyl-D-aspartic acid receptors Neurochemistry Neurodegenerative diseases Neurology Neuroprotection Neuroprotection - drug effects Neuroprotection - physiology Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Neurotransmission Object recognition Original Paper Pattern recognition Phosphorylation Pretreatment Proteomics Receptors Sarcosine - analogs & derivatives Sarcosine - pharmacology Sarcosine - therapeutic use Spatial analysis Spatial memory Spine Synapses Synaptic depression TrkB receptors β-Amyloid
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