The cell biology of ferroptosis

Ferroptosis is a non-apoptotic cell death mechanism characterized by iron-dependent membrane lipid peroxidation. Here, we review what is known about the cellular mechanisms mediating the execution and regulation of ferroptosis. We first consider how the accumulation of membrane lipid peroxides leads...

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Bibliographic Details
Published in:Nature reviews. Molecular cell biology 2024-06, Vol.25 (6), p.424-442
Main Authors: Dixon, Scott J., Olzmann, James A.
Format: Article
Language:English
Subjects:
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Animals
Apoptosis
Biochemistry
Biology
Biomedical and Life Sciences
Cancer Research
Cell Biology
Cell death
Cell Membrane - metabolism
Compartments
Developmental Biology
Endoplasmic reticulum
Ferroptosis
Ferroptosis - physiology
Humans
Ion transport
Iron
Iron - metabolism
Life Sciences
Lipid Metabolism
Lipid Peroxidation
Lipids
Membranes
Metabolic pathways
Metabolism
Metabolites
Mitochondria - metabolism
Mortality
Organelles
Oxidation-Reduction
Peroxidation
Peroxides
Review Article
Sensitivity
Stem Cells
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