TCF/LEF dependent and independent transcriptional regulation of Wnt/β‐catenin target genes

During canonical Wnt signalling, the activity of nuclear β‐catenin is largely mediated by the TCF/LEF family of transcription factors. To challenge this view, we used the CRISPR/Cas9 genome editing approach to generate HEK 293T cell clones lacking all four TCF/LEF genes. By performing unbiased whole...

Full description

Saved in:

Bibliographic Details
Published in:	The EMBO journal 2019-01, Vol.38 (2), p.n/a
Main Authors:	Doumpas, Nikolaos, Lampart, Franziska, Robinson, Mark D, Lentini, Antonio, Nestor, Colm E, Cantù, Claudio, Basler, Konrad
Format:	Article
Language:	English
Subjects:	beta Catenin - metabolism Catenin CRISPR CRISPR-Cas Systems Deoxyribonucleic acid DNA EMBO37 EMBO44 FOXO4 protein Gene Editing Gene expression Gene Expression Profiling - methods Gene Expression Regulation Gene regulation Gene sequencing Genes Genome editing Genomes HEK293 Cells Humans LEF protein Signal transduction signalling pathways TCF Transcription Factors - genetics TCF Transcription Factors - metabolism TCF/LEF Transcription factors Transcription, Genetic Whole Exome Sequencing - methods Wnt protein Wnt Signaling Pathway Wnt signalling β‐catenin
Citations:	Items that this one cites Items that cite this one
Online Access:	Request full text
Tags:	Add Tag No Tags, Be the first to tag this record!