Arterial baroreflex dysfunction after coronary artery bypass grafting

a Department of Internal Medicine, Varberg Hospital, SE 432 81 Varberg, Sweden b Department Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden c School of Social and Health Sciences, Halmstad University, Halmstad, Sweden *Corresponding author. Tel.: +46 340-481000; fax: +46 340-1...

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Bibliographic Details
Published in:Interactive cardiovascular and thoracic surgery 2009-04, Vol.8 (4), p.426-430
Main Authors: Johansson, Mats, Karlsson, Ann-Kristin, Myredal, Anna, Lidell, Evy
Format: Article
Language:English
Subjects:
Adult
Aged
Arterial baroreflex function
Arteries - physiopathology
Baroreflex
Blood Pressure
CABG
Case-Control Studies
Coronary Artery Bypass - adverse effects
Electrocardiography
Female
Heart Rate
Humans
Male
MEDICIN
MEDICINE
Middle Aged
Parasympathetic Nervous System - physiopathology
Recovery of Function
Tachycardia, Ventricular - etiology
Tachycardia, Ventricular - physiopathology
Time Factors
Treatment Outcome
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Summary:a Department of Internal Medicine, Varberg Hospital, SE 432 81 Varberg, Sweden b Department Clinical Physiology, Sahlgrenska University Hospital, Göteborg, Sweden c School of Social and Health Sciences, Halmstad University, Halmstad, Sweden *Corresponding author. Tel.: +46 340-481000; fax: +46 340-17343. E-mail address : matsjohans{at}telia.com (M. Johansson). Although uncommon, the incidence of ventricular arrhythmia is high in certain subsets of patients after coronary artery bypass grafting. Arterial baroreflex dysfunction has been linked to increased risk of ventricular arrhythmia and sudden cardiac death. The aim of the current study was to explore arterial baroreflex function during the early recovery phase and up to five months after surgery. Electrocardiogram and beat-to-beat blood pressures were registered in patients ( n =92) undergoing coronary artery bypass grafting five weeks and five months after surgery. Healthy subjects ( n =31) were examined for comparison. The arterial baroreflex sensitivity and the baroreflex effectiveness index were calculated. The baroreflex sensitivity and the baroreflex effectiveness index were reduced by 36% and 64%, respectively ( P
ISSN:1569-9293
1569-9285
1569-9285
DOI:10.1510/icvts.2008.198747