Differential Gene Expression of Vascular Natriuretic Peptide Receptor Subtype in Artery and Vein

Although the vasorelaxation by natriuretic peptide (NP) is much less potent in the vein than in the artery, mechanism underlying the phenomenon remains unknown. Since NP receptor consists of three subtypes with different functions, we determined the mRNA level of each NP receptor subtype in the arte...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 1995-11, Vol.216 (2), p.535-539
Main Authors: Yoshimoto, T., Naruse, M., Naruse, K., Shionoya, K., Tanabe, A., Tanaka, M., Hagiwara, H., Hirose, S., Muraki, T., Demura, H.
Format: Article
Language:English
Subjects:
Animals
Antisense Elements (Genetics)
Aorta - metabolism
Gene Expression
Guanylate Cyclase - biosynthesis
Male
Muscle, Smooth, Vascular - metabolism
Organ Specificity
Rats
Rats, Wistar
Receptors, Atrial Natriuretic Factor - biosynthesis
Ribonucleases
RNA Probes
RNA, Messenger - analysis
RNA, Messenger - metabolism
Vena Cava, Inferior - metabolism
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Summary:Although the vasorelaxation by natriuretic peptide (NP) is much less potent in the vein than in the artery, mechanism underlying the phenomenon remains unknown. Since NP receptor consists of three subtypes with different functions, we determined the mRNA level of each NP receptor subtype in the artery and vein by ribonuclease protection assay. In the aorta, NP-A receptor related to the biological action of NP was the predominant form. By contrast, NP-C receptor related mainly to the clearance of NP was the predominant form in the inferior vena cava: NP-C mRNA level was about two fold higher than in the aorta, while both NP-A and NP-B receptor mRNA levels were about half of that in the aorta. These results provide the molecular basis for the different biological response to NP in the artery and vein. Differential gene expression of NP receptor subtype could be an important determinant of the biological actions of NP.
ISSN:0006-291X
1090-2104
1090-2104
DOI:10.1006/bbrc.1995.2655