Medical and psychosocial factors and unfavourable low-density lipoprotein cholesterol control in coronary patients

• Published in: European journal of preventive cardiology 2017-06, Vol.24 (9), p.981-989
• Main Authors: Munkhaugen, John, Sverre, Elise, Otterstad, Jan E, Peersen, Kari, Gjertsen, Erik, Perk, Joep, Gullestad, Lars, Moum, Torbjørn, Dammen, Toril, Husebye, Einar
• Format: Article
• Language: English
• Subjects: Aged; Biomarkers - blood; Chi-Square Distribution; Cholesterol, LDL - blood; Coronary Artery Bypass; Coronary Artery Disease - blood; Coronary Artery Disease - diagnosis; Coronary Artery Disease - psychology; Coronary Artery Disease - therapy; Coronary heart disease; Cross-Sectional Studies; Drug adherence; Dyslipidemias - blood; Dyslipidemias - diagnosis; Dyslipidemias - drug therapy; Dyslipidemias - psychology; Female; Health and Caring Sciences; Healthy Diet; Hospitalization; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors - adverse effects; Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use; Hälsovetenskap; Linear Models; Logistic Models; Low-density lipoprotein cholesterol; Male; Medication Adherence; Middle Aged; Multivariate Analysis; Myocardial Infarction - blood; Myocardial Infarction - diagnosis; Myocardial Infarction - psychology; Myocardial Infarction - therapy; Norway; Odds Ratio; Percutaneous Coronary Intervention; Psychosocial factors; Retrospective Studies; Risk Factors; Risk Reduction Behavior; Seafood; Secondary prevention; Self Report; Socioeconomic Factors; Time Factors; Treatment Outcome
• ISSN: 2047-4873; 2047-4881; 2047-4881
• DOI: 10.1177/2047487317693134

Objective Understanding the determinants of low-density lipoprotein cholesterol (LDL-C) control constitutes the basis of modelling interventions for optimal lipid control and prognosis. We aim to identify medical and psychosocial (study) factors associated with unfavourable LDL-C control in coronary patients. Methods A cross-sectional explorative study used logistic and linear regression analysis to investigate the association between study factors and LDL-C in 1095 patients, hospitalized with myocardial infarction and/or a coronary revascularization procedure. Data were collected from hospital records, a comprehensive self-report questionnaire, clinical examination and blood samples after 2–36 months follow-up. Results Fifty-seven per cent did not reach the LDL-C target of 1.8 mmol/l at follow-up. Low socioeconomic status and psychosocial factors were not associated with failure to reach the LDL-C target. Statin specific side-effects (odds ratio 3.23), low statin adherence (odds ratio 3.07), coronary artery by-pass graft operation as index treatment (odds ratio 1.95), ≥ 1 coronary event prior to the index event (odds ratio 1.81), female gender (odds ratio 1.80), moderate- or low-intensity statin therapy (odds ratio 1.62) and eating fish