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Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue
A vital role of adrenoceptors in metabolism and energy balance has been well documented in the heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of the mechanistic target of rapamycin (mTOR) makes a significant contribution to various metabo...
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| Published in: | British journal of pharmacology 2019-07, Vol.176 (14), p.2433-2448 |
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| Main Authors: | , , , , , |
| Format: | Article |
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| cites | cdi_FETCH-LOGICAL-c5466-e9201ce5c1c2bbf27090f0fa1d624d890d8e2606c33a8aaa6acf655ec2cbc6cc3 |
| container_end_page | 2448 |
| container_issue | 14 |
| container_start_page | 2433 |
| container_title | British journal of pharmacology |
| container_volume | 176 |
| creator | Chia, Ling Yeong Evans, Bronwyn A. Mukaida, Saori Bengtsson, Tore Hutchinson, Dana S. Sato, Masaaki |
| description | A vital role of adrenoceptors in metabolism and energy balance has been well documented in the heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of the mechanistic target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1 and 2 as a novel paradigm of adrenoceptor signalling in the heart, skeletal muscle, and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions.
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This article is part of a themed section on Adrenoceptors—New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc |
| doi_str_mv | 10.1111/bph.14616 |
| format | article |
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Linked Articles
This article is part of a themed section on Adrenoceptors—New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc</description><subject>Adipose tissue</subject><subject>Adipose Tissue - drug effects</subject><subject>Adipose Tissue - metabolism</subject><subject>Adrenergic beta-Agonists - pharmacology</subject><subject>Adrenergic receptors</subject><subject>Animals</subject><subject>Cell proliferation</subject><subject>Energy balance</subject><subject>Energy metabolism</subject><subject>Humans</subject><subject>Hypertrophy</subject><subject>Mitochondria</subject><subject>Muscle, Skeletal - drug effects</subject><subject>Muscle, Skeletal - metabolism</subject><subject>Muscles</subject><subject>Musculoskeletal system</subject><subject>Physiological responses</subject><subject>Physiology</subject><subject>Protein biosynthesis</subject><subject>Protein synthesis</subject><subject>Rapamycin</subject><subject>Receptors (physiology)</subject><subject>Review</subject><subject>Sirolimus - agonists</subject><subject>Sirolimus - metabolism</subject><subject>Skeletal muscle</subject><subject>Themed Section: Review</subject><subject>Therapeutic applications</subject><subject>TOR protein</subject><issn>0007-1188</issn><issn>1476-5381</issn><issn>1476-5381</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2019</creationdate><recordtype>article</recordtype><recordid>eNp1kVFr1TAYhoMo7mx64R-QgjcK65akTZreCMfpnDDQC_XGi5B-_XpORtvUJHWcf7-cdQ43MARy8T55-PheQl4xesLSOW2m7QkrJZNPyIqVlcxFodhTsqKUVjljSh2QwxCuKE1hJZ6Tg4JWJZWyXJFf69bj6ACn6HzmcTP3Jlo3Zq7L4hazAWFrRhuihSwav8G4T7yZzLADO2bpDnOAHjMztplp7eQCZtGGMOML8qwzfcCXd-8R-XH-6fvZRX759fOXs_VlDqKUMseaUwYogAFvmo5XtKYd7QxrJS9bVdNWIZdUQlEYZYyRBjopBAKHBiRAcUSOF2-4xmlu9OTtYPxOO2P1R_tzrZ3f6DBrVlHFWcLfL3hiB2wBx-hN_-DXw2S0W71xf7QUNVeyTIK3dwLvfs8Yoh5sAOx7M6Kbg-acipKJgsmEvnmEXrnZj2kbiaolr5Wq9sJ3CwXeheCxux-GUb1vWKeG9W3DiX397_T35N9KE3C6ANe2x93_TfrDt4tFeQMNSLIN</recordid><startdate>201907</startdate><enddate>201907</enddate><creator>Chia, Ling Yeong</creator><creator>Evans, Bronwyn A.</creator><creator>Mukaida, Saori</creator><creator>Bengtsson, Tore</creator><creator>Hutchinson, Dana S.</creator><creator>Sato, Masaaki</creator><general>Blackwell Publishing Ltd</general><general>John Wiley and Sons Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope><scope>5PM</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>DG7</scope><orcidid>https://orcid.org/0000-0003-0564-4318</orcidid><orcidid>https://orcid.org/0000-0001-9947-0106</orcidid></search><sort><creationdate>201907</creationdate><title>Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue</title><author>Chia, Ling Yeong ; Evans, Bronwyn A. ; Mukaida, Saori ; Bengtsson, Tore ; Hutchinson, Dana S. ; Sato, Masaaki</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5466-e9201ce5c1c2bbf27090f0fa1d624d890d8e2606c33a8aaa6acf655ec2cbc6cc3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2019</creationdate><topic>Adipose tissue</topic><topic>Adipose Tissue - drug effects</topic><topic>Adipose Tissue - metabolism</topic><topic>Adrenergic beta-Agonists - pharmacology</topic><topic>Adrenergic receptors</topic><topic>Animals</topic><topic>Cell proliferation</topic><topic>Energy balance</topic><topic>Energy metabolism</topic><topic>Humans</topic><topic>Hypertrophy</topic><topic>Mitochondria</topic><topic>Muscle, Skeletal - drug effects</topic><topic>Muscle, Skeletal - metabolism</topic><topic>Muscles</topic><topic>Musculoskeletal system</topic><topic>Physiological responses</topic><topic>Physiology</topic><topic>Protein biosynthesis</topic><topic>Protein synthesis</topic><topic>Rapamycin</topic><topic>Receptors (physiology)</topic><topic>Review</topic><topic>Sirolimus - agonists</topic><topic>Sirolimus - metabolism</topic><topic>Skeletal muscle</topic><topic>Themed Section: Review</topic><topic>Therapeutic applications</topic><topic>TOR protein</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Chia, Ling Yeong</creatorcontrib><creatorcontrib>Evans, Bronwyn A.</creatorcontrib><creatorcontrib>Mukaida, Saori</creatorcontrib><creatorcontrib>Bengtsson, Tore</creatorcontrib><creatorcontrib>Hutchinson, Dana S.</creatorcontrib><creatorcontrib>Sato, Masaaki</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Stockholms universitet</collection><jtitle>British journal of pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Chia, Ling Yeong</au><au>Evans, Bronwyn A.</au><au>Mukaida, Saori</au><au>Bengtsson, Tore</au><au>Hutchinson, Dana S.</au><au>Sato, Masaaki</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue</atitle><jtitle>British journal of pharmacology</jtitle><addtitle>Br J Pharmacol</addtitle><date>2019-07</date><risdate>2019</risdate><volume>176</volume><issue>14</issue><spage>2433</spage><epage>2448</epage><pages>2433-2448</pages><issn>0007-1188</issn><issn>1476-5381</issn><eissn>1476-5381</eissn><abstract>A vital role of adrenoceptors in metabolism and energy balance has been well documented in the heart, skeletal muscle, and adipose tissue. It has been only recently demonstrated, however, that activation of the mechanistic target of rapamycin (mTOR) makes a significant contribution to various metabolic and physiological responses to adrenoceptor agonists. mTOR exists as two distinct complexes named mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2) and has been shown to play a critical role in protein synthesis, cell proliferation, hypertrophy, mitochondrial function, and glucose uptake. This review will describe the physiological significance of mTORC1 and 2 as a novel paradigm of adrenoceptor signalling in the heart, skeletal muscle, and adipose tissue. Understanding the detailed signalling cascades of adrenoceptors and how they regulate physiological responses is important for identifying new therapeutic targets and identifying novel therapeutic interventions.
Linked Articles
This article is part of a themed section on Adrenoceptors—New Roles for Old Players. To view the other articles in this section visit http://onlinelibrary.wiley.com/doi/10.1111/bph.v176.14/issuetoc</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>30740664</pmid><doi>10.1111/bph.14616</doi><tpages>16</tpages><orcidid>https://orcid.org/0000-0003-0564-4318</orcidid><orcidid>https://orcid.org/0000-0001-9947-0106</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | British journal of pharmacology, 2019-07, Vol.176 (14), p.2433-2448 |
| issn | 0007-1188 1476-5381 1476-5381 |
| language | eng |
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| source | Wiley-Blackwell Read & Publish Collection; PubMed Central |
| subjects | Adipose tissue Adipose Tissue - drug effects Adipose Tissue - metabolism Adrenergic beta-Agonists - pharmacology Adrenergic receptors Animals Cell proliferation Energy balance Energy metabolism Humans Hypertrophy Mitochondria Muscle, Skeletal - drug effects Muscle, Skeletal - metabolism Muscles Musculoskeletal system Physiological responses Physiology Protein biosynthesis Protein synthesis Rapamycin Receptors (physiology) Review Sirolimus - agonists Sirolimus - metabolism Skeletal muscle Themed Section: Review Therapeutic applications TOR protein |
| title | Adrenoceptor regulation of the mechanistic target of rapamycin in muscle and adipose tissue |
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