Adiposity Without Obesity: Associations with Osteoporosis, Sarcopenia, and Falls in the Healthy Ageing Initiative Cohort Study

Objective Obesity is commonly defined by BMI rather than adiposity, which may have differential effects on musculoskeletal health. Musculoskeletal outcomes were compared in older adults with normal adiposity and normal BMI (NA‐NBMI), those with high adiposity but normal BMI (HA‐NBMI), and those with...

Full description

Saved in:
Bibliographic Details
Published in:Obesity (Silver Spring, Md.) Md.), 2020-11, Vol.28 (11), p.2232-2241
Main Authors: Scott, David, Johansson, Jonas, Ebeling, Peter R., Nordstrom, Peter, Nordstrom, Anna
Format: Article
Language:English
Subjects:
Accidental Falls - statistics & numerical data
Adiposity - physiology
Aged
Body composition
Body fat
Cohort analysis
Cohort Studies
Community medicine, Social medicine: 801
Female
Fractures
Health sciences: 800
Healthy Aging
Helsefag: 800
Humans
Male
Medical disciplines: 700
Medisinske Fag: 700
Obesity
Older people
Osteoporosis
Osteoporosis - etiology
Samfunnsmedisin, sosialmedisin: 801
Sarcopenia
Sarcopenia - etiology
VDP
Women
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Objective Obesity is commonly defined by BMI rather than adiposity, which may have differential effects on musculoskeletal health. Musculoskeletal outcomes were compared in older adults with normal adiposity and normal BMI (NA‐NBMI), those with high adiposity but normal BMI (HA‐NBMI), and those with high adiposity and high BMI (HA‐HBMI). Methods In 3,411 70‐year‐olds, obesity was defined as BMI ≥ 30 kg/m2 and adiposity as body fat percentage ≥ 25% (men) or ≥ 35% (women) from dual‐energy x‐ray absorptiometry. Bone parameters were measured by dual‐energy x‐ray absorptiometry and peripheral quantitative computed tomography. Sarcopenia was defined as low handgrip strength with or without low appendicular lean mass. Falls were self‐reported 6 and 12 months later. Results Prevalence of NA‐NBMI, HA‐NBMI, and HA‐HBMI was 14.2%, 68.1%, and 17.7%, respectively. Compared with HA‐HBMI, HA‐NBMI had increased likelihood for sarcopenia (adjusted odds ratio: 3.99; 95% CI: 1.41‐11.32) and osteoporosis (2.91; 95% CI: 2.35‐3.61) but similar likelihood of falls (P > 0.05). HA‐NBMI had lower values for bone geometry parameters, as well as grip strength, than both NA‐NBMI and HA‐HBMI (all P 
ISSN:1930-7381
1930-739X
1930-739X
DOI:10.1002/oby.22984