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Adiposity Without Obesity: Associations with Osteoporosis, Sarcopenia, and Falls in the Healthy Ageing Initiative Cohort Study
Objective Obesity is commonly defined by BMI rather than adiposity, which may have differential effects on musculoskeletal health. Musculoskeletal outcomes were compared in older adults with normal adiposity and normal BMI (NA‐NBMI), those with high adiposity but normal BMI (HA‐NBMI), and those with...
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| Published in: | Obesity (Silver Spring, Md.) Md.), 2020-11, Vol.28 (11), p.2232-2241 |
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| container_issue | 11 |
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| container_title | Obesity (Silver Spring, Md.) |
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| creator | Scott, David Johansson, Jonas Ebeling, Peter R. Nordstrom, Peter Nordstrom, Anna |
| description | Objective
Obesity is commonly defined by BMI rather than adiposity, which may have differential effects on musculoskeletal health. Musculoskeletal outcomes were compared in older adults with normal adiposity and normal BMI (NA‐NBMI), those with high adiposity but normal BMI (HA‐NBMI), and those with high adiposity and high BMI (HA‐HBMI).
Methods
In 3,411 70‐year‐olds, obesity was defined as BMI ≥ 30 kg/m2 and adiposity as body fat percentage ≥ 25% (men) or ≥ 35% (women) from dual‐energy x‐ray absorptiometry. Bone parameters were measured by dual‐energy x‐ray absorptiometry and peripheral quantitative computed tomography. Sarcopenia was defined as low handgrip strength with or without low appendicular lean mass. Falls were self‐reported 6 and 12 months later.
Results
Prevalence of NA‐NBMI, HA‐NBMI, and HA‐HBMI was 14.2%, 68.1%, and 17.7%, respectively. Compared with HA‐HBMI, HA‐NBMI had increased likelihood for sarcopenia (adjusted odds ratio: 3.99; 95% CI: 1.41‐11.32) and osteoporosis (2.91; 95% CI: 2.35‐3.61) but similar likelihood of falls (P > 0.05). HA‐NBMI had lower values for bone geometry parameters, as well as grip strength, than both NA‐NBMI and HA‐HBMI (all P |
| doi_str_mv | 10.1002/oby.22984 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_swepu</sourceid><recordid>TN_cdi_swepub_primary_oai_DiVA_org_umu_176099</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2460797508</sourcerecordid><originalsourceid>FETCH-LOGICAL-c4504-6d8f333c6b14e37b2bdd2cde38c0785087acb0d7fad639cc37bf11ac35435a0f3</originalsourceid><addsrcrecordid>eNp10ctu3CAUBmCratWkaRd9gRapm1aKEy62sbNzp81FijSL9LpCGPAMkQdcLh15k2cPEyezqNQVID7-A5wse4vgCYIQn9puOsG4qYtn2SFqCMwpaX49389rdJC98v4WwqKCJXqZHRACEUaEHmZ3rdSj9TpM4KcOaxsDWHZqtz4DrfdWaB60NR5s0y5Y-qDsaF064I_BDXfCjspofgy4keCcD4MH2oCwVuBS8SGsJ9CulDYrcGV02EX9VWBh19YFcBOinF5nL3o-ePXmcTzKvp9__ba4zK-XF1eL9joXRQmLvJJ1TwgRVYcKRWiHOymxkIrUAtK6hDXlooOS9lxWpBEikR4hLkhZkJLDnhxl-Zzrt2qMHRud3nA3Mcs1-6J_tMy6FYubyBCtYNMk_372wmkftGHGOs7SZxPKMEKwSuLjLEZn_0TlA9toL9QwcKNs9AwXRZ3uUpU00Q__0FsbnUnvTaqCtKHpBUl9eippvXeq318SwV1lzFKb2UObk333mBi7jZJ7-dTXBE5nsNWDmv6fxJaff8-R9-aksWo</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2460797508</pqid></control><display><type>article</type><title>Adiposity Without Obesity: Associations with Osteoporosis, Sarcopenia, and Falls in the Healthy Ageing Initiative Cohort Study</title><source>NORA - Norwegian Open Research Archives</source><source>Wiley-Blackwell Read & Publish Collection</source><creator>Scott, David ; Johansson, Jonas ; Ebeling, Peter R. ; Nordstrom, Peter ; Nordstrom, Anna</creator><creatorcontrib>Scott, David ; Johansson, Jonas ; Ebeling, Peter R. ; Nordstrom, Peter ; Nordstrom, Anna</creatorcontrib><description>Objective
Obesity is commonly defined by BMI rather than adiposity, which may have differential effects on musculoskeletal health. Musculoskeletal outcomes were compared in older adults with normal adiposity and normal BMI (NA‐NBMI), those with high adiposity but normal BMI (HA‐NBMI), and those with high adiposity and high BMI (HA‐HBMI).
Methods
In 3,411 70‐year‐olds, obesity was defined as BMI ≥ 30 kg/m2 and adiposity as body fat percentage ≥ 25% (men) or ≥ 35% (women) from dual‐energy x‐ray absorptiometry. Bone parameters were measured by dual‐energy x‐ray absorptiometry and peripheral quantitative computed tomography. Sarcopenia was defined as low handgrip strength with or without low appendicular lean mass. Falls were self‐reported 6 and 12 months later.
Results
Prevalence of NA‐NBMI, HA‐NBMI, and HA‐HBMI was 14.2%, 68.1%, and 17.7%, respectively. Compared with HA‐HBMI, HA‐NBMI had increased likelihood for sarcopenia (adjusted odds ratio: 3.99; 95% CI: 1.41‐11.32) and osteoporosis (2.91; 95% CI: 2.35‐3.61) but similar likelihood of falls (P > 0.05). HA‐NBMI had lower values for bone geometry parameters, as well as grip strength, than both NA‐NBMI and HA‐HBMI (all P < 0.05).
Conclusions
High adiposity without high BMI is more common than BMI‐defined obesity in older Swedish adults but does not provide similar protection from osteoporosis and sarcopenia.</description><identifier>ISSN: 1930-7381</identifier><identifier>ISSN: 1930-739X</identifier><identifier>EISSN: 1930-739X</identifier><identifier>DOI: 10.1002/oby.22984</identifier><identifier>PMID: 33012137</identifier><language>eng</language><publisher>United States: Blackwell Publishing Ltd</publisher><subject>Accidental Falls - statistics & numerical data ; Adiposity - physiology ; Aged ; Body composition ; Body fat ; Cohort analysis ; Cohort Studies ; Community medicine, Social medicine: 801 ; Female ; Fractures ; Health sciences: 800 ; Healthy Aging ; Helsefag: 800 ; Humans ; Male ; Medical disciplines: 700 ; Medisinske Fag: 700 ; Obesity ; Older people ; Osteoporosis ; Osteoporosis - etiology ; Samfunnsmedisin, sosialmedisin: 801 ; Sarcopenia ; Sarcopenia - etiology ; VDP ; Women</subject><ispartof>Obesity (Silver Spring, Md.), 2020-11, Vol.28 (11), p.2232-2241</ispartof><rights>2020 The Obesity Society</rights><rights>2020 The Obesity Society.</rights><rights>Copyright Blackwell Publishing Ltd. Nov 2020</rights><rights>info:eu-repo/semantics/openAccess</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4504-6d8f333c6b14e37b2bdd2cde38c0785087acb0d7fad639cc37bf11ac35435a0f3</citedby><cites>FETCH-LOGICAL-c4504-6d8f333c6b14e37b2bdd2cde38c0785087acb0d7fad639cc37bf11ac35435a0f3</cites><orcidid>0000-0001-5226-1972</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,26567,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/33012137$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-176099$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Scott, David</creatorcontrib><creatorcontrib>Johansson, Jonas</creatorcontrib><creatorcontrib>Ebeling, Peter R.</creatorcontrib><creatorcontrib>Nordstrom, Peter</creatorcontrib><creatorcontrib>Nordstrom, Anna</creatorcontrib><title>Adiposity Without Obesity: Associations with Osteoporosis, Sarcopenia, and Falls in the Healthy Ageing Initiative Cohort Study</title><title>Obesity (Silver Spring, Md.)</title><addtitle>Obesity (Silver Spring)</addtitle><description>Objective
Obesity is commonly defined by BMI rather than adiposity, which may have differential effects on musculoskeletal health. Musculoskeletal outcomes were compared in older adults with normal adiposity and normal BMI (NA‐NBMI), those with high adiposity but normal BMI (HA‐NBMI), and those with high adiposity and high BMI (HA‐HBMI).
Methods
In 3,411 70‐year‐olds, obesity was defined as BMI ≥ 30 kg/m2 and adiposity as body fat percentage ≥ 25% (men) or ≥ 35% (women) from dual‐energy x‐ray absorptiometry. Bone parameters were measured by dual‐energy x‐ray absorptiometry and peripheral quantitative computed tomography. Sarcopenia was defined as low handgrip strength with or without low appendicular lean mass. Falls were self‐reported 6 and 12 months later.
Results
Prevalence of NA‐NBMI, HA‐NBMI, and HA‐HBMI was 14.2%, 68.1%, and 17.7%, respectively. Compared with HA‐HBMI, HA‐NBMI had increased likelihood for sarcopenia (adjusted odds ratio: 3.99; 95% CI: 1.41‐11.32) and osteoporosis (2.91; 95% CI: 2.35‐3.61) but similar likelihood of falls (P > 0.05). HA‐NBMI had lower values for bone geometry parameters, as well as grip strength, than both NA‐NBMI and HA‐HBMI (all P < 0.05).
Conclusions
High adiposity without high BMI is more common than BMI‐defined obesity in older Swedish adults but does not provide similar protection from osteoporosis and sarcopenia.</description><subject>Accidental Falls - statistics & numerical data</subject><subject>Adiposity - physiology</subject><subject>Aged</subject><subject>Body composition</subject><subject>Body fat</subject><subject>Cohort analysis</subject><subject>Cohort Studies</subject><subject>Community medicine, Social medicine: 801</subject><subject>Female</subject><subject>Fractures</subject><subject>Health sciences: 800</subject><subject>Healthy Aging</subject><subject>Helsefag: 800</subject><subject>Humans</subject><subject>Male</subject><subject>Medical disciplines: 700</subject><subject>Medisinske Fag: 700</subject><subject>Obesity</subject><subject>Older people</subject><subject>Osteoporosis</subject><subject>Osteoporosis - etiology</subject><subject>Samfunnsmedisin, sosialmedisin: 801</subject><subject>Sarcopenia</subject><subject>Sarcopenia - etiology</subject><subject>VDP</subject><subject>Women</subject><issn>1930-7381</issn><issn>1930-739X</issn><issn>1930-739X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2020</creationdate><recordtype>article</recordtype><sourceid>3HK</sourceid><recordid>eNp10ctu3CAUBmCratWkaRd9gRapm1aKEy62sbNzp81FijSL9LpCGPAMkQdcLh15k2cPEyezqNQVID7-A5wse4vgCYIQn9puOsG4qYtn2SFqCMwpaX49389rdJC98v4WwqKCJXqZHRACEUaEHmZ3rdSj9TpM4KcOaxsDWHZqtz4DrfdWaB60NR5s0y5Y-qDsaF064I_BDXfCjspofgy4keCcD4MH2oCwVuBS8SGsJ9CulDYrcGV02EX9VWBh19YFcBOinF5nL3o-ePXmcTzKvp9__ba4zK-XF1eL9joXRQmLvJJ1TwgRVYcKRWiHOymxkIrUAtK6hDXlooOS9lxWpBEikR4hLkhZkJLDnhxl-Zzrt2qMHRud3nA3Mcs1-6J_tMy6FYubyBCtYNMk_372wmkftGHGOs7SZxPKMEKwSuLjLEZn_0TlA9toL9QwcKNs9AwXRZ3uUpU00Q__0FsbnUnvTaqCtKHpBUl9eippvXeq318SwV1lzFKb2UObk333mBi7jZJ7-dTXBE5nsNWDmv6fxJaff8-R9-aksWo</recordid><startdate>202011</startdate><enddate>202011</enddate><creator>Scott, David</creator><creator>Johansson, Jonas</creator><creator>Ebeling, Peter R.</creator><creator>Nordstrom, Peter</creator><creator>Nordstrom, Anna</creator><general>Blackwell Publishing Ltd</general><general>Wiley</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><scope>3HK</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope><orcidid>https://orcid.org/0000-0001-5226-1972</orcidid></search><sort><creationdate>202011</creationdate><title>Adiposity Without Obesity: Associations with Osteoporosis, Sarcopenia, and Falls in the Healthy Ageing Initiative Cohort Study</title><author>Scott, David ; Johansson, Jonas ; Ebeling, Peter R. ; Nordstrom, Peter ; Nordstrom, Anna</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4504-6d8f333c6b14e37b2bdd2cde38c0785087acb0d7fad639cc37bf11ac35435a0f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2020</creationdate><topic>Accidental Falls - statistics & numerical data</topic><topic>Adiposity - physiology</topic><topic>Aged</topic><topic>Body composition</topic><topic>Body fat</topic><topic>Cohort analysis</topic><topic>Cohort Studies</topic><topic>Community medicine, Social medicine: 801</topic><topic>Female</topic><topic>Fractures</topic><topic>Health sciences: 800</topic><topic>Healthy Aging</topic><topic>Helsefag: 800</topic><topic>Humans</topic><topic>Male</topic><topic>Medical disciplines: 700</topic><topic>Medisinske Fag: 700</topic><topic>Obesity</topic><topic>Older people</topic><topic>Osteoporosis</topic><topic>Osteoporosis - etiology</topic><topic>Samfunnsmedisin, sosialmedisin: 801</topic><topic>Sarcopenia</topic><topic>Sarcopenia - etiology</topic><topic>VDP</topic><topic>Women</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Scott, David</creatorcontrib><creatorcontrib>Johansson, Jonas</creatorcontrib><creatorcontrib>Ebeling, Peter R.</creatorcontrib><creatorcontrib>Nordstrom, Peter</creatorcontrib><creatorcontrib>Nordstrom, Anna</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>NORA - Norwegian Open Research Archives</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><jtitle>Obesity (Silver Spring, Md.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Scott, David</au><au>Johansson, Jonas</au><au>Ebeling, Peter R.</au><au>Nordstrom, Peter</au><au>Nordstrom, Anna</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Adiposity Without Obesity: Associations with Osteoporosis, Sarcopenia, and Falls in the Healthy Ageing Initiative Cohort Study</atitle><jtitle>Obesity (Silver Spring, Md.)</jtitle><addtitle>Obesity (Silver Spring)</addtitle><date>2020-11</date><risdate>2020</risdate><volume>28</volume><issue>11</issue><spage>2232</spage><epage>2241</epage><pages>2232-2241</pages><issn>1930-7381</issn><issn>1930-739X</issn><eissn>1930-739X</eissn><abstract>Objective
Obesity is commonly defined by BMI rather than adiposity, which may have differential effects on musculoskeletal health. Musculoskeletal outcomes were compared in older adults with normal adiposity and normal BMI (NA‐NBMI), those with high adiposity but normal BMI (HA‐NBMI), and those with high adiposity and high BMI (HA‐HBMI).
Methods
In 3,411 70‐year‐olds, obesity was defined as BMI ≥ 30 kg/m2 and adiposity as body fat percentage ≥ 25% (men) or ≥ 35% (women) from dual‐energy x‐ray absorptiometry. Bone parameters were measured by dual‐energy x‐ray absorptiometry and peripheral quantitative computed tomography. Sarcopenia was defined as low handgrip strength with or without low appendicular lean mass. Falls were self‐reported 6 and 12 months later.
Results
Prevalence of NA‐NBMI, HA‐NBMI, and HA‐HBMI was 14.2%, 68.1%, and 17.7%, respectively. Compared with HA‐HBMI, HA‐NBMI had increased likelihood for sarcopenia (adjusted odds ratio: 3.99; 95% CI: 1.41‐11.32) and osteoporosis (2.91; 95% CI: 2.35‐3.61) but similar likelihood of falls (P > 0.05). HA‐NBMI had lower values for bone geometry parameters, as well as grip strength, than both NA‐NBMI and HA‐HBMI (all P < 0.05).
Conclusions
High adiposity without high BMI is more common than BMI‐defined obesity in older Swedish adults but does not provide similar protection from osteoporosis and sarcopenia.</abstract><cop>United States</cop><pub>Blackwell Publishing Ltd</pub><pmid>33012137</pmid><doi>10.1002/oby.22984</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0001-5226-1972</orcidid><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity (Silver Spring, Md.), 2020-11, Vol.28 (11), p.2232-2241 |
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| source | NORA - Norwegian Open Research Archives; Wiley-Blackwell Read & Publish Collection |
| subjects | Accidental Falls - statistics & numerical data Adiposity - physiology Aged Body composition Body fat Cohort analysis Cohort Studies Community medicine, Social medicine: 801 Female Fractures Health sciences: 800 Healthy Aging Helsefag: 800 Humans Male Medical disciplines: 700 Medisinske Fag: 700 Obesity Older people Osteoporosis Osteoporosis - etiology Samfunnsmedisin, sosialmedisin: 801 Sarcopenia Sarcopenia - etiology VDP Women |
| title | Adiposity Without Obesity: Associations with Osteoporosis, Sarcopenia, and Falls in the Healthy Ageing Initiative Cohort Study |
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