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Association between HbA 1c and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes
To explore the association between HbA and sural nerve function in a group of people with normal glucose tolerance, impaired glucose tolerance or Type 2 diabetes. We conducted a 10-year follow-up study in 87 out of an original 119 participants. At study commencement (2004), 64 men and 55 women (mean...
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| Published in: | Diabetic medicine 2017-12, Vol.34 (12), p.1756-1764 |
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| container_end_page | 1764 |
| container_issue | 12 |
| container_start_page | 1756 |
| container_title | Diabetic medicine |
| container_volume | 34 |
| creator | Peterson, M Pingel, R Lagali, N Dahlin, L B Rolandsson, O |
| description | To explore the association between HbA
and sural nerve function in a group of people with normal glucose tolerance, impaired glucose tolerance or Type 2 diabetes.
We conducted a 10-year follow-up study in 87 out of an original 119 participants. At study commencement (2004), 64 men and 55 women (mean age 61.1 years) with normal glucose tolerance (n=39), impaired glucose tolerance (n=29), or Type 2 diabetes (n=51) were enrolled. At the 2014 follow-up (men, n=46, women, n=41; mean age 71.1 years), 36, nine and 42 participants in the normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes categories, respectively, were re-tested. Biometric data and blood samples were collected, with an electrophysiological examination performed on both occasions.
At follow-up, we measured the amplitude of the sural nerve in 74 of the 87 participants. The mean amplitude had decreased from 10.9 μV (2004) to 7.0 μV (2014; P |
| doi_str_mv | 10.1111/dme.13514 |
| format | article |
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and sural nerve function in a group of people with normal glucose tolerance, impaired glucose tolerance or Type 2 diabetes.
We conducted a 10-year follow-up study in 87 out of an original 119 participants. At study commencement (2004), 64 men and 55 women (mean age 61.1 years) with normal glucose tolerance (n=39), impaired glucose tolerance (n=29), or Type 2 diabetes (n=51) were enrolled. At the 2014 follow-up (men, n=46, women, n=41; mean age 71.1 years), 36, nine and 42 participants in the normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes categories, respectively, were re-tested. Biometric data and blood samples were collected, with an electrophysiological examination performed on both occasions.
At follow-up, we measured the amplitude of the sural nerve in 74 of the 87 participants. The mean amplitude had decreased from 10.9 μV (2004) to 7.0 μV (2014; P<0.001). A 1% increase in HbA
was associated with a ~1% average decrease in the amplitude of the sural nerve, irrespective of group classification. Crude and adjusted estimates ranged from -0.84 (95% CI -1.32, -0.37) to -1.25 (95% CI -2.31, -0.18). Although the mean conduction velocity of those measured at both occasions (n=73) decreased from 47.6 m/s to 45.8 m/s (P=0.009), any association with HbA
level was weak. Results were robust with regard to potential confounders and missing data.
Our data suggest an association between sural nerve amplitude and HbA
at all levels of HbA
. Decreased amplitude was more pronounced than was diminished conduction velocity, supporting the notion that axonal degeneration is an earlier and more prominent effect of hyperglycaemia than demyelination.</description><identifier>ISSN: 0742-3071</identifier><identifier>ISSN: 1464-5491</identifier><identifier>EISSN: 1464-5491</identifier><identifier>DOI: 10.1111/dme.13514</identifier><identifier>PMID: 28929513</identifier><language>eng</language><publisher>England</publisher><subject>Aged ; Blood Glucose - metabolism ; Diabetes Mellitus, Type 2 - blood ; Diabetes Mellitus, Type 2 - epidemiology ; Diabetic Neuropathies - blood ; Diabetic Neuropathies - epidemiology ; Female ; Follow-Up Studies ; Glucose Intolerance - blood ; Glucose Intolerance - epidemiology ; Glucose Tolerance Test ; Glycated Hemoglobin A - metabolism ; Humans ; Male ; Middle Aged ; Risk Factors ; Sweden - epidemiology</subject><ispartof>Diabetic medicine, 2017-12, Vol.34 (12), p.1756-1764</ispartof><rights>2017 Diabetes UK.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c1729-43a09ede9ce1c244591768aacda4700f43ab66388c5be130b9ba3fbd16109d503</citedby><cites>FETCH-LOGICAL-c1729-43a09ede9ce1c244591768aacda4700f43ab66388c5be130b9ba3fbd16109d503</cites><orcidid>0000-0001-9523-3971</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>230,314,780,784,885,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28929513$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-142449$$DView record from Swedish Publication Index$$Hfree_for_read</backlink><backlink>$$Uhttps://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-342209$$DView record from Swedish Publication Index$$Hfree_for_read</backlink></links><search><creatorcontrib>Peterson, M</creatorcontrib><creatorcontrib>Pingel, R</creatorcontrib><creatorcontrib>Lagali, N</creatorcontrib><creatorcontrib>Dahlin, L B</creatorcontrib><creatorcontrib>Rolandsson, O</creatorcontrib><title>Association between HbA 1c and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes</title><title>Diabetic medicine</title><addtitle>Diabet Med</addtitle><description>To explore the association between HbA
and sural nerve function in a group of people with normal glucose tolerance, impaired glucose tolerance or Type 2 diabetes.
We conducted a 10-year follow-up study in 87 out of an original 119 participants. At study commencement (2004), 64 men and 55 women (mean age 61.1 years) with normal glucose tolerance (n=39), impaired glucose tolerance (n=29), or Type 2 diabetes (n=51) were enrolled. At the 2014 follow-up (men, n=46, women, n=41; mean age 71.1 years), 36, nine and 42 participants in the normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes categories, respectively, were re-tested. Biometric data and blood samples were collected, with an electrophysiological examination performed on both occasions.
At follow-up, we measured the amplitude of the sural nerve in 74 of the 87 participants. The mean amplitude had decreased from 10.9 μV (2004) to 7.0 μV (2014; P<0.001). A 1% increase in HbA
was associated with a ~1% average decrease in the amplitude of the sural nerve, irrespective of group classification. Crude and adjusted estimates ranged from -0.84 (95% CI -1.32, -0.37) to -1.25 (95% CI -2.31, -0.18). Although the mean conduction velocity of those measured at both occasions (n=73) decreased from 47.6 m/s to 45.8 m/s (P=0.009), any association with HbA
level was weak. Results were robust with regard to potential confounders and missing data.
Our data suggest an association between sural nerve amplitude and HbA
at all levels of HbA
. Decreased amplitude was more pronounced than was diminished conduction velocity, supporting the notion that axonal degeneration is an earlier and more prominent effect of hyperglycaemia than demyelination.</description><subject>Aged</subject><subject>Blood Glucose - metabolism</subject><subject>Diabetes Mellitus, Type 2 - blood</subject><subject>Diabetes Mellitus, Type 2 - epidemiology</subject><subject>Diabetic Neuropathies - blood</subject><subject>Diabetic Neuropathies - epidemiology</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glucose Intolerance - blood</subject><subject>Glucose Intolerance - epidemiology</subject><subject>Glucose Tolerance Test</subject><subject>Glycated Hemoglobin A - metabolism</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Risk Factors</subject><subject>Sweden - epidemiology</subject><issn>0742-3071</issn><issn>1464-5491</issn><issn>1464-5491</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><recordid>eNqNkUFv1DAQhS0EotvCgT-AfEVqisd2kvVxVUqLVIlL26vl2JOuURJbdqJVfhL_sm4XeuHCXOYw33vzpEfIJ2AXUOarG_ECRA3yDdmAbGRVSwVvyYa1kleCtXBCTnP-xRhwJdR7csK3iqsaxIb83uUcrDezDxPtcD4gTvSm21Gw1EyORkw-7jGZgU64pBDNvF-pn6ihwKoVTaJ9GIZwqJZI87y4lYa-qEIckB78vKdTSGNRPw6LDRnpHIbiNlk8p36Mxid0_95eXt-tESmnzpuSC_MH8q43Q8aPf_YZuf9-dXd5U93-vP5xubutLLRcVVIYptChsgiWS1kraJutMdYZ2TLWl3vXNGK7tXWHIFinOiP6zkEDTLmaiTNyfvTNB4xLp2Pyo0mrDsbrb_5hp0N61MuiheScqYJX_4GPiwZZ0jzzX468TSHnhP2rAph-blOXNvVLm4X9fGSL8Yjulfxbn3gCITCdXw</recordid><startdate>201712</startdate><enddate>201712</enddate><creator>Peterson, M</creator><creator>Pingel, R</creator><creator>Lagali, N</creator><creator>Dahlin, L B</creator><creator>Rolandsson, O</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>ADTPV</scope><scope>AOWAS</scope><scope>D93</scope><scope>DF2</scope><orcidid>https://orcid.org/0000-0001-9523-3971</orcidid></search><sort><creationdate>201712</creationdate><title>Association between HbA 1c and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes</title><author>Peterson, M ; Pingel, R ; Lagali, N ; Dahlin, L B ; Rolandsson, O</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c1729-43a09ede9ce1c244591768aacda4700f43ab66388c5be130b9ba3fbd16109d503</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Aged</topic><topic>Blood Glucose - metabolism</topic><topic>Diabetes Mellitus, Type 2 - blood</topic><topic>Diabetes Mellitus, Type 2 - epidemiology</topic><topic>Diabetic Neuropathies - blood</topic><topic>Diabetic Neuropathies - epidemiology</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glucose Intolerance - blood</topic><topic>Glucose Intolerance - epidemiology</topic><topic>Glucose Tolerance Test</topic><topic>Glycated Hemoglobin A - metabolism</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Risk Factors</topic><topic>Sweden - epidemiology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Peterson, M</creatorcontrib><creatorcontrib>Pingel, R</creatorcontrib><creatorcontrib>Lagali, N</creatorcontrib><creatorcontrib>Dahlin, L B</creatorcontrib><creatorcontrib>Rolandsson, O</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>SwePub</collection><collection>SwePub Articles</collection><collection>SWEPUB Umeå universitet</collection><collection>SWEPUB Uppsala universitet</collection><jtitle>Diabetic medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Peterson, M</au><au>Pingel, R</au><au>Lagali, N</au><au>Dahlin, L B</au><au>Rolandsson, O</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Association between HbA 1c and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes</atitle><jtitle>Diabetic medicine</jtitle><addtitle>Diabet Med</addtitle><date>2017-12</date><risdate>2017</risdate><volume>34</volume><issue>12</issue><spage>1756</spage><epage>1764</epage><pages>1756-1764</pages><issn>0742-3071</issn><issn>1464-5491</issn><eissn>1464-5491</eissn><abstract>To explore the association between HbA
and sural nerve function in a group of people with normal glucose tolerance, impaired glucose tolerance or Type 2 diabetes.
We conducted a 10-year follow-up study in 87 out of an original 119 participants. At study commencement (2004), 64 men and 55 women (mean age 61.1 years) with normal glucose tolerance (n=39), impaired glucose tolerance (n=29), or Type 2 diabetes (n=51) were enrolled. At the 2014 follow-up (men, n=46, women, n=41; mean age 71.1 years), 36, nine and 42 participants in the normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes categories, respectively, were re-tested. Biometric data and blood samples were collected, with an electrophysiological examination performed on both occasions.
At follow-up, we measured the amplitude of the sural nerve in 74 of the 87 participants. The mean amplitude had decreased from 10.9 μV (2004) to 7.0 μV (2014; P<0.001). A 1% increase in HbA
was associated with a ~1% average decrease in the amplitude of the sural nerve, irrespective of group classification. Crude and adjusted estimates ranged from -0.84 (95% CI -1.32, -0.37) to -1.25 (95% CI -2.31, -0.18). Although the mean conduction velocity of those measured at both occasions (n=73) decreased from 47.6 m/s to 45.8 m/s (P=0.009), any association with HbA
level was weak. Results were robust with regard to potential confounders and missing data.
Our data suggest an association between sural nerve amplitude and HbA
at all levels of HbA
. Decreased amplitude was more pronounced than was diminished conduction velocity, supporting the notion that axonal degeneration is an earlier and more prominent effect of hyperglycaemia than demyelination.</abstract><cop>England</cop><pmid>28929513</pmid><doi>10.1111/dme.13514</doi><tpages>9</tpages><orcidid>https://orcid.org/0000-0001-9523-3971</orcidid></addata></record> |
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| identifier | ISSN: 0742-3071 |
| ispartof | Diabetic medicine, 2017-12, Vol.34 (12), p.1756-1764 |
| issn | 0742-3071 1464-5491 1464-5491 |
| language | eng |
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| source | Wiley |
| subjects | Aged Blood Glucose - metabolism Diabetes Mellitus, Type 2 - blood Diabetes Mellitus, Type 2 - epidemiology Diabetic Neuropathies - blood Diabetic Neuropathies - epidemiology Female Follow-Up Studies Glucose Intolerance - blood Glucose Intolerance - epidemiology Glucose Tolerance Test Glycated Hemoglobin A - metabolism Humans Male Middle Aged Risk Factors Sweden - epidemiology |
| title | Association between HbA 1c and peripheral neuropathy in a 10-year follow-up study of people with normal glucose tolerance, impaired glucose tolerance and Type 2 diabetes |
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